Literature DB >> 24271417

Effect of reserpine on adenylate cyclase system of rat striatum.

K Kumakura1, A Carenzi, P F Spano, M Trabucchi.   

Abstract

We have investigated the properties of dopamine-dependent adenylate cyclase in rat striatal homogenates, 20 h after reserpine treatment. In this experimental condition, we have found that the affinity of the enzyme for dopamine is greatly enhanced. On the other hand, the concentration of apomorphine required to produced half-maximal activation of the enzyme in striatal homogenates of controls and reserpine-treated rats is not changed. The unchanged affinity of adenylate cyclase for the substrate (ATP:Mg(++)) indicates that reserpine probably affects the receptor component of the enzyme.

Entities:  

Year:  1976        PMID： 24271417     DOI： 10.1007/BF00973777

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  17 in total

Review 1.  Action of opiates, antipsychotics, amphetamine and apomorphine on dopamine receptors in rat striatum: in vivo changes of 3',5'-cyclic AMP content and acetylcholine turnover rate.

Authors:  A Carenzi; D L Cheney; E Costa; A Guidotti; G Racagni
Journal:  Neuropharmacology       Date:  1975-12       Impact factor: 5.250

2.  Dopaminergic denervation supersensitivity and dopamine stimulated adenyl cyclase activity.

Authors:  P F Von Voigtlander; S J Boukma; G A Johnson
Journal:  Neuropharmacology       Date:  1973-11       Impact factor: 5.250

3.  Electrophysiological evidence for involvement of cyclic adenosine monophosphate in dopamine responses of caudate neurons.

Authors:  G R Siggins; B J Hoffer; U Ungerstedt
Journal:  Life Sci       Date:  1974-08-15       Impact factor: 5.037

4.  Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".

Authors:  J W Kebabian; G L Petzold; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

5.  Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol.

Authors:  G Gianutsos; R B Drawbaugh; M D Hynes; H Lal
Journal:  Life Sci       Date:  1974-03-01       Impact factor: 5.037

6.  On the mechanism of supersensitivity to norepinephrine in the denervated cat spleen.

Authors:  S Brimijoin; S Pluchino; U Trendelenburg
Journal:  J Pharmacol Exp Ther       Date:  1970-11       Impact factor: 4.030

7.  Dopamine-sensitive adenylyl cyclase in human caudate nucleus. A study in control subjects and schizophrenic patients.

Authors:  A Carenzi; J C Gillin; A Guidotti; M A Schwartz; M Trabucchi; R J Wyatt
Journal:  Arch Gen Psychiatry       Date:  1975-08

8.  D-amphetamine-induced release of "newly synthesized" and "stored" dopamine from the caudate nucleus in vivo.

Authors:  C C Chiueh; K E Moore
Journal:  J Pharmacol Exp Ther       Date:  1975-03       Impact factor: 4.030

9.  Enhancement of dopamine-stimulated adenylate cyclase activity in rat caudate after lesions in substantia nigra: evidence for denervation supersensitivity.

Authors:  R K Mishra; E L Gardner; R Katzman; M H Makman
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

10.  Adenyl cyclase activity in rat pineal gland: effects of chronic denervation and norepinephrine.

Authors:  B Weiss; E Costa
Journal:  Science       Date:  1967-06-30       Impact factor: 47.728
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