Literature DB >> 24271131

High-performance liquid chromatographic analysis of tocainide in human plasma.

L Conings1, N Verbeke.   

Abstract

A method for the determination of tocainide, a new antiarrhythmic drug, by means of ion-pair High Performance Liquid Chromatography (HPLC), is described. The drug and its chemically related internal standard are extracted from the basified plasma sample with methylene chloride. The organic extract is evaporated to dryness, dissolved in the mobile phase and chromatographed on a µ-Bondapak C-18 reversed phase column under radial compression. The detection limit is 200 ng/ml. The main metabolites as well as some frequently used antiarrhythmic drugs do not interfere in the assay.

Entities:  

Year:  1985        PMID： 24271131     DOI： 10.1023/A:1016353903999

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  20 in total

1.  Suppression of ventricular ectopic depolarizations by tocainide.

Authors:  R L Woosley; D G McDevitt; A S Nies; R F Smith; G R Wilkinson; J A Oates
Journal:  Circulation       Date:  1977-12       Impact factor: 29.690

2.  High-performance liquid chromatographic assay for tocainide in human plasma: comparison with gas--liquid chromatographic assay.

Authors:  P A Reece; P E Stanley
Journal:  J Chromatogr       Date:  1980-07-11

3.  Simple method for the measurement of tocainide and lignocaine in blood plasma or serum using gas--liquid chromatography with flame ionisation detection.

Authors:  S D Gettings; R J Flanagan; D W Holt
Journal:  J Chromatogr       Date:  1981-10-09

4.  Assay of tocainide in blood by high-pressure liquid chromatography.

Authors:  E M Wolshin; M H Cavanaugh; C V Manion; M B Meyer; E Milano; C R Reardon; S M Wolshin
Journal:  J Pharm Sci       Date:  1978-12       Impact factor: 3.534

5.  Antiarrhythmic effects of a lidocaine congener, tocainide, 2-amino-2',6'-propionoxylidide, in man.

Authors:  D G McDevitt; A S Nies; G R Wilkinson; R F Smith; R L Woosley; J A Oates
Journal:  Clin Pharmacol Ther       Date:  1976-04       Impact factor: 6.875

6.  Kinetics of the oral antiarrhythmic lidocaine congener, tocainide.

Authors:  D Lalka; M B Meyer; B R Duce; A T Elvin
Journal:  Clin Pharmacol Ther       Date:  1976-06       Impact factor: 6.875

7.  Tocainide conjugation in humans: novel biotransformation pathway for a primary amine.

Authors:  A T Elvin; J B Keenaghan; E W Byrnes; P A Tenthorey; P D McMaster; B H Takman; D Lalka; C V Manion; D T Baer; E M Wolshin; M B Meyer; R A Ronfeld
Journal:  J Pharm Sci       Date:  1980-01       Impact factor: 3.534

8.  Determination of tocainide in human plasma by gas chromatography with nitrogen-selective detection after Schiff base formation.

Authors:  L Johansson; J Vessman
Journal:  J Chromatogr       Date:  1982-04-30

9.  Electron-capture gas-liquid chromatographic determination of tocainide in biological fluids using fused silica capillary columns.

Authors:  G K Pillai; J E Axelson; K M McErlane
Journal:  J Chromatogr       Date:  1982-04-16

10.  High-pressure liquid chromatographic analysis of drugs in biological fluids II: determination of an antiarrhythmic drug, tocainide, as its dansyl derivative using a fluorescence detector.

Authors:  P J Meffin; S R Harapat; D C Harrison
Journal:  J Pharm Sci       Date:  1977-04       Impact factor: 3.534
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