Literature DB >> 24271120

Leukotriene biosynthesis inhibitors.

J R Cashman1.   

Abstract

This review describes the design and current development of leukotriene biosynthesis inhibitors as potential antiinflammatory agents. Knowledge of the enzymatic mechanism of 5-lipoxygenase led to specific inhibitors of this enzyme which catalyzes a key step in the leukotriene pathway. Competitive inhibitors include iron chelators, redox agents and alternate substrates. Further, the potential of product inhibitors and mechanism based inactivators of 5-lipoxygenase is discussed.

Entities:  

Year:  1985        PMID： 24271120     DOI： 10.1023/A:1016381215385

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  87 in total

1.  Demonstration by EPR spectroscopy of the functional role of iron in soybean lipoxygenase-1.

Authors:  J J de Groot; G A Veldink; J F Vliegenthart; J Boldingh; R Wever; B F van Gelder
Journal:  Biochim Biophys Acta       Date:  1975-01-23

2.  Subcellular localization of enzymes involved in leukotriene formation within human polymorphonuclear granulocytes.

Authors:  J Brom; M Raulf; M Stüning; B Spur; A Crea; K D Bremm; W König
Journal:  Immunology       Date:  1984-03       Impact factor: 7.397

Review 3.  Prostaglandins.

Authors:  B Samuelsson; E Granström; K Green; M Hamberg; S Hammarström
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

Review 4.  Endogenous anti-inflammatory factors.

Authors:  D A Lewis
Journal:  Biochem Pharmacol       Date:  1984-06-01       Impact factor: 5.858

5.  3-N-substituted-amino-1-[3-(trifluoromethyl)phenyl]-2-pyrazolines have enhanced activity against arachidonate 5-lipoxygenase and cyclooxygenase.

Authors:  F C Copp; P J Islip; J E Tateson
Journal:  Biochem Pharmacol       Date:  1984-01-15       Impact factor: 5.858

6.  The mechanism of inactivation of lipoxygenases by acetylenic fatty acids.

Authors:  H Kühn; H G Holzhütter; T Schewe; C Hiebsch; S M Rapoport
Journal:  Eur J Biochem       Date:  1984-03-15

7.  Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases.

Authors:  P Borgeat; M Hamberg; B Samuelsson
Journal:  J Biol Chem       Date:  1976-12-25       Impact factor: 5.157

8.  Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.

Authors:  M K Bach; J R Brashler; D R Morton
Journal:  Arch Biochem Biophys       Date:  1984-05-01       Impact factor: 4.013

9.  Transformations of 5,8,11,14,17-eicosapentaenoic acid in human platelets.

Authors:  M Hamberg
Journal:  Biochim Biophys Acta       Date:  1980-06-23

10.  Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.

Authors:  B Samuelsson
Journal:  Science       Date:  1983-05-06       Impact factor: 47.728
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  5 in total

1.  Role of prostaglandins and leukotrienes in volume regulation by Ehrlich ascites tumor cells.

Authors:  I H Lambert; E K Hoffmann; P Christensen
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

2.  Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells.

Authors:  Khalequz Zaman; Marie H Hanigan; Alison Smith; John Vaughan; Timothy Macdonald; David R Jones; John F Hunt; Benjamin Gaston
Journal:  Am J Respir Cell Mol Biol       Date:  2006-01-13       Impact factor: 6.914

Review 3.  Perspectives in corticosteroid research.

Authors:  M Töpert
Journal:  Drugs       Date:  1988       Impact factor: 9.546

4.  Leukotriene-D4 induced cell shrinkage in Ehrlich ascites tumor cells.

Authors:  I H Lambert
Journal:  J Membr Biol       Date:  1989-05       Impact factor: 1.843

5.  Regulation of taurine transport in Ehrlich ascites tumor cells.

Authors:  I H Lambert; E K Hoffmann
Journal:  J Membr Biol       Date:  1993-01       Impact factor: 1.843
  5 in total

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