Literature DB >> 6249377

Transformations of 5,8,11,14,17-eicosapentaenoic acid in human platelets.

M Hamberg.   

Abstract

5,8,11,14,17-[1-14C]Eicosapentaenoic acid was prepared biosynthetically from [1-14C]arachidonic acid using the fungus, Saprolegnia parasitica. Incubation of 5,8,11,14,17-[1-14C]eicosapentaenoic acid with suspensions of human platelets led to the formation of three labeled compounds which were identified as thromboxane B3 (2-5% yield), 12-hydroxy-5,8,10,14-heptadecatetraenoic acid (2-5% yield), and 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid (7-59% yield).

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Year:  1980        PMID： 6249377     DOI： 10.1016/0005-2760(80)90257-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  15 in total

1.  12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Authors:  Luiz Osório Leiria; Chih-Hao Wang; Matthew D Lynes; Kunyan Yang; Farnaz Shamsi; Mari Sato; Satoru Sugimoto; Emily Y Chen; Valerie Bussberg; Niven R Narain; Brian E Sansbury; Justin Darcy; Tian Lian Huang; Sean D Kodani; Masaji Sakaguchi; Andréa L Rocha; Tim J Schulz; Alexander Bartelt; Gökhan S Hotamisligil; Michael F Hirshman; Klaus van Leyen; Laurie J Goodyear; Matthias Blüher; Aaron M Cypess; Michael A Kiebish; Matthew Spite; Yu-Hua Tseng
Journal:  Cell Metab       Date:  2019-07-25       Impact factor: 27.287

2.  Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells.

Authors:  G Liu; D M Bibus; A M Bode; W Y Ma; R T Holman; Z Dong
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-19       Impact factor: 11.205

3.  Vasoactive effects of eicosapentaenoic acid on isolated vascular smooth muscle.

Authors:  A Yanagisawa; A M Lefer
Journal:  Basic Res Cardiol       Date:  1987 Mar-Apr       Impact factor: 17.165

4.  The effect of a fish oil diet on the fatty acid composition of individual phospholipids and eicosanoid production by rat platelets.

Authors:  M Careaga-Houck; H Sprecher
Journal:  Lipids       Date:  1989-06       Impact factor: 1.880

5.  Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids.

Authors:  C Miller; R Y Yamaguchi; V A Ziboh
Journal:  Lipids       Date:  1989-12       Impact factor: 1.880

6.  Fatty acid composition of tissue phospholipids and prostaglandin excretion in hyperlipidemia induced in rats by implantation of the mammotropic pituitary tumor MtT-F4.

Authors:  Y S Huang; A Martineau; P Falardeau; J Davignon
Journal:  Lipids       Date:  1983-06       Impact factor: 1.880

7.  [In vitro studies of the effect of different mixture proportions of omega-3 and omega-6 fatty acids on thrombocyte aggregation and thromboxane synthesis in human thrombocytes].

Authors:  S Stroh; I Elmadfa
Journal:  Z Ernahrungswiss       Date:  1991-09

8.  Production of prostaglandins in homogenates of kidney medullae and cortices of spontaneously hypertensive rats fed menhaden oil.

Authors:  N W Schoene; A Ferretti; D Fiore
Journal:  Lipids       Date:  1981-11       Impact factor: 1.880

9.  Identification and quantification of prostaglandin E3 in renal medullary tissue of three strains of rats fed fish oil.

Authors:  A Ferretti; N W Schoene; V P Flanagan
Journal:  Lipids       Date:  1981-11       Impact factor: 1.880

10.  Uptake, stimulated release and metabolism of (1-14C)-eicosapentaenoic acid in a perfused organ of the rabbit.

Authors:  H Juan; W Sametz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-11       Impact factor: 3.000
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