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Literature DB >> 24270444

Recurrent H3.3 alterations in childhood tumors.

Abstract

Comprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers.

Entities: Disease Gene

Mesh：

Substances：
Histones

Year: 2013 PMID： 24270444 DOI： 10.1038/ng.2832

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

14 in total

1. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.

Authors: Jeremy Schwartzentruber; Andrey Korshunov; Xiao-Yang Liu; David T W Jones; Elke Pfaff; Karine Jacob; Dominik Sturm; Adam M Fontebasso; Dong-Anh Khuong Quang; Martje Tönjes; Volker Hovestadt; Steffen Albrecht; Marcel Kool; Andre Nantel; Carolin Konermann; Anders Lindroth; Natalie Jäger; Tobias Rausch; Marina Ryzhova; Jan O Korbel; Thomas Hielscher; Peter Hauser; Miklos Garami; Almos Klekner; Laszlo Bognar; Martin Ebinger; Martin U Schuhmann; Wolfram Scheurlen; Arnulf Pekrun; Michael C Frühwald; Wolfgang Roggendorf; Christoph Kramm; Matthias Dürken; Jeffrey Atkinson; Pierre Lepage; Alexandre Montpetit; Magdalena Zakrzewska; Krzystof Zakrzewski; Pawel P Liberski; Zhifeng Dong; Peter Siegel; Andreas E Kulozik; Marc Zapatka; Abhijit Guha; David Malkin; Jörg Felsberg; Guido Reifenberger; Andreas von Deimling; Koichi Ichimura; V Peter Collins; Hendrik Witt; Till Milde; Olaf Witt; Cindy Zhang; Pedro Castelo-Branco; Peter Lichter; Damien Faury; Uri Tabori; Christoph Plass; Jacek Majewski; Stefan M Pfister; Nada Jabado
Journal: Nature Date: 2012-01-29 Impact factor: 49.962

2. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.

Authors: Sebastian Bender; Yujie Tang; Anders M Lindroth; Volker Hovestadt; David T W Jones; Marcel Kool; Marc Zapatka; Paul A Northcott; Dominik Sturm; Wei Wang; Bernhard Radlwimmer; Jonas W Højfeldt; Nathalène Truffaux; David Castel; Simone Schubert; Marina Ryzhova; Huriye Seker-Cin; Jan Gronych; Pascal David Johann; Sebastian Stark; Jochen Meyer; Till Milde; Martin Schuhmann; Martin Ebinger; Camelia-Maria Monoranu; Anitha Ponnuswami; Spenser Chen; Chris Jones; Olaf Witt; V Peter Collins; Andreas von Deimling; Nada Jabado; Stephanie Puget; Jacques Grill; Kristian Helin; Andrey Korshunov; Peter Lichter; Michelle Monje; Christoph Plass; Yoon-Jae Cho; Stefan M Pfister
Journal: Cancer Cell Date: 2013-10-31 Impact factor: 31.743

Review 3. The human histone H3 complement anno 2011.

Authors: Thomas H A Ederveen; Imke K Mandemaker; Colin Logie
Journal: Biochim Biophys Acta Date: 2011-07-14

4. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.

Authors: Fredrik J Swartling; Vasil Savov; Anders I Persson; Justin Chen; Christopher S Hackett; Paul A Northcott; Matthew R Grimmer; Jasmine Lau; Louis Chesler; Arie Perry; Joanna J Phillips; Michael D Taylor; William A Weiss
Journal: Cancer Cell Date: 2012-05-15 Impact factor: 31.743

5. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.

Authors: Gary C Hon; R David Hawkins; Otavia L Caballero; Christine Lo; Ryan Lister; Mattia Pelizzola; Armand Valsesia; Zhen Ye; Samantha Kuan; Lee E Edsall; Anamaria Aranha Camargo; Brian J Stevenson; Joseph R Ecker; Vineet Bafna; Robert L Strausberg; Andrew J Simpson; Bing Ren
Journal: Genome Res Date: 2011-12-07 Impact factor: 9.043

6. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

Authors: Peter W Lewis; Manuel M Müller; Matthew S Koletsky; Francisco Cordero; Shu Lin; Laura A Banaszynski; Benjamin A Garcia; Tom W Muir; Oren J Becher; C David Allis
Journal: Science Date: 2013-03-28 Impact factor: 47.728

7. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

Authors: Kui-Ming Chan; Dong Fang; Haiyun Gan; Rintaro Hashizume; Chuanhe Yu; Mark Schroeder; Nalin Gupta; Sabine Mueller; C David James; Robert Jenkins; Jann Sarkaria; Zhiguo Zhang
Journal: Genes Dev Date: 2013-04-19 Impact factor: 11.361

8. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

Authors: Sam Behjati; Patrick S Tarpey; Nadège Presneau; Susanne Scheipl; Nischalan Pillay; Peter Van Loo; David C Wedge; Susanna L Cooke; Gunes Gundem; Helen Davies; Serena Nik-Zainal; Sancha Martin; Stuart McLaren; Victoria Goodie; Ben Robinson; Adam Butler; Jon W Teague; Dina Halai; Bhavisha Khatri; Ola Myklebost; Daniel Baumhoer; Gernot Jundt; Rifat Hamoudi; Roberto Tirabosco; M Fernanda Amary; P Andrew Futreal; Michael R Stratton; Peter J Campbell; Adrienne M Flanagan
Journal: Nat Genet Date: 2013-10-27 Impact factor: 38.330

9. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.

Authors: Anders M Lindroth; Yoon Jung Park; Chelsea M McLean; Gregoriy A Dokshin; Jenna M Persson; Herry Herman; Diego Pasini; Xavier Miró; Mary E Donohoe; Jeannie T Lee; Kristian Helin; Paul D Soloway
Journal: PLoS Genet Date: 2008-08-01 Impact factor: 5.917

10. Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.

Authors: James P Reddington; Sara M Perricone; Colm E Nestor; Judith Reichmann; Neil A Youngson; Masako Suzuki; Diana Reinhardt; Donncha S Dunican; James G Prendergast; Heidi Mjoseng; Bernard H Ramsahoye; Emma Whitelaw; John M Greally; Ian R Adams; Wendy A Bickmore; Richard R Meehan
Journal: Genome Biol Date: 2013-03-25 Impact factor: 13.583

12 in total

Recurrent H3.3 alterations in childhood tumors.

1. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.

2. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.

Review 3. The human histone H3 complement anno 2011.

4. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.

5. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.

6. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

7. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

8. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

9. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.

10. Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.

1. PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly.

2. Rpp29 regulates histone H3.3 chromatin assembly through transcriptional mechanisms.

Review 3. Recent advances and future of immunotherapy for glioblastoma.

Review 4. The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.

Review 5. Pathologic conditions of hard tissue: role of osteoclasts in osteolytic lesion.

6. Consent procedures in pediatric biobanks.

Review 7. Insight into the pathogenesis and nature of Central Giant Cell Lesions of the Jaws.

8. Personalized assent for pediatric biobanks.

9. RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition.

10. Histone variant H3F3A promotes lung cancer cell migration through intronic regulation.