| Literature DB >> 24269684 |
Lei Yang1, Yan-Li Wang1, Shang Liu1, Pei-Pei Zhang1, Zheng Chen1, Min Liu1, Hua Tang2.
Abstract
MicroRNAs are a class of small, endogenous, non-coding RNAs that function as post-transcriptional regulators. In this study, we found that miR-181b promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells. And we validated a new miR-181b target gene, adenylyl cyclase 9 (AC9). miR-181b restricted cAMP production by post-transcriptionally downregulating AC9 expression. Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis.Entities:
Keywords: AC9; ASO; Adenylyl cyclase 9; Cervical cancer cell; EGFP; GAPDH; TUNEL; UTR; adenylyl cyclase 9; antisense oligonucleotide; cAMP; enhanced green fluorescence protein; glyceraldehyde-3-phosphate dehydrogenase; miR-181b; miRNA; microRNA; microRNA-181b; terminal deoxynucleotidyl transferase dUTP nick end labeling; untranslated region
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Year: 2013 PMID： 24269684 DOI： 10.1016/j.febslet.2013.11.019
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124