Literature DB >> 24269514

Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates.

Diego Faccone1, Omar Veliz1, Alejandra Corso1, Martin Noguera2, Melina Martínez3, Cristian Payes4, Liliana Semorile3, Paulo Cesar Maffía5.   

Abstract

Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).
Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Keywords:  Antimicrobial; Cationic; Peptides; Resistance

Mesh：

Substances：

Year:  2013        PMID： 24269514     DOI： 10.1016/j.ejmech.2013.10.065

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  11 in total

1.  Interaction between Antibacterial Peptide Apep10 and Escherichia coli Membrane Lipids Evaluated Using Liposome as Pseudo-Stationary Phase.

Authors:  Wenting Tang; Chuanfen Pu; Man Li
Journal:  PLoS One       Date:  2017-01-04       Impact factor: 3.240

2.  Cationic Antimicrobial Peptides Inactivate Shiga Toxin-Encoding Bacteriophages.

Authors:  Manuel E Del Cogliano; Axel Hollmann; Melina Martinez; Liliana Semorile; Pablo D Ghiringhelli; Paulo C Maffía; Leticia V Bentancor
Journal:  Front Chem       Date:  2017-12-19       Impact factor: 5.221

3.  Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides.

Authors:  Damian Neubauer; Maciej Jaśkiewicz; Dorian Migoń; Marta Bauer; Karol Sikora; Emilia Sikorska; Elżbieta Kamysz; Wojciech Kamysz
Journal:  Amino Acids       Date:  2017-07-29       Impact factor: 3.520

4.  Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides.

Authors:  Ammar Almaaytah; Mohammed T Qaoud; Ahmad Abualhaijaa; Qosay Al-Balas; Karem H Alzoubi
Journal:  Infect Drug Resist       Date:  2018-06-01       Impact factor: 4.003

Review 5.  Antimicrobial Peptides: Interaction With Model and Biological Membranes and Synergism With Chemical Antibiotics.

Authors:  Axel Hollmann; Melina Martinez; Patricia Maturana; Liliana C Semorile; Paulo C Maffia
Journal:  Front Chem       Date:  2018-06-05       Impact factor: 5.221

Review 6.  Host defense peptides: An insight into the antimicrobial world.

Authors:  Shiva Gupta; Gouri Bhatia; Anamika Sharma; Sameer Saxena
Journal:  J Oral Maxillofac Pathol       Date:  2018 May-Aug

Review 7.  How Melittin Inserts into Cell Membrane: Conformational Changes, Inter-Peptide Cooperation, and Disturbance on the Membrane.

Authors:  Jiajia Hong; Xuemei Lu; Zhixiong Deng; Shufeng Xiao; Bing Yuan; Kai Yang
Journal:  Molecules       Date:  2019-05-07       Impact factor: 4.411

8.  Conjugation of Cell-Penetrating Peptides to Antimicrobial Peptides Enhances Antibacterial Activity.

Authors:  Hyunhee Lee; Sung In Lim; Sung-Heui Shin; Yong Lim; Jae Woong Koh; Sungtae Yang
Journal:  ACS Omega       Date:  2019-09-09

Review 9.  Computer-Aided Design of Antimicrobial Peptides: Are We Generating Effective Drug Candidates?

Authors:  Marlon H Cardoso; Raquel Q Orozco; Samilla B Rezende; Gisele Rodrigues; Karen G N Oshiro; Elizabete S Cândido; Octávio L Franco
Journal:  Front Microbiol       Date:  2020-01-22       Impact factor: 5.640

Review 10.  Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response.

Authors:  Derry K Mercer; Deborah A O'Neil
Journal:  Front Immunol       Date:  2020-09-17       Impact factor: 7.561
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