| Literature DB >> 24267282 |
Edythe M Lyn Greenberg1, Alexandra Probst.
Abstract
The chronic leukemias include chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL). CML is a clonal myeloproliferative hematopoietic stem-cell disorder, and CLL is a monoclonal B-cell disorder. CML is Philadelphia chromosome positive. There are 3 phases of CML: the chronic phase, the accelerated phase, and the blast phase. The primary treatment of CML consists of tyrosine kinase inhibitors. CLL can present as indolent or fulminant disease. Early disease is managed with observation. Fulminant disease is currently treated with alkylating agents, purine analogues, and monoclonal antibodies, but new biotarged therapies are being developed.Entities:
Keywords: Alkylating agents; Chronic lymphocytic leukemia; Chronic myeloid leukemia; Immunomodulatory agents; Leukocytosis; Lymphocytosis; Monoclonal antibodies; Tyrosine kinase inhibitors
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Year: 2013 PMID： 24267282 DOI： 10.1016/j.ccell.2013.09.003
Source DB: PubMed Journal: Crit Care Nurs Clin North Am ISSN： 0899-5885 Impact factor: 1.326