BACKGROUND: Preeclampsia is characterized by hypertension, dyslipidemia, and systemic inflammatory response. The aim of this study was to determine the level of serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1) and high-sensitive C-reactive protein (hsCRP) in preeclampsia and to compare normal pregnant, mild preeclamptic, and severe preeclamptic women. METHODS: A cross-sectional study was conducted to determine the plasma concentrations of sVCAM-1 and hsCRP in peripheral blood obtained from normal pregnant (n = 40), mild preeclamptic (n = 37), and severe preeclamptic women (n = 38). A concentration of soluble adhesion molecule was determined with enzyme-linked immunosorbent assay. hsCRP was measured with immunoturbidometric. RESULTS: There was significant difference in the means serum hsCRP between normal pregnant women and mild preeclamptic women (P < 0.05). Serum concentration of hsCRP and sVCAM-1 (ng/mL) were significantly higher in severe preeclampsia (P < 0.05) than normal pregnancy. There were also significant differences in hsCRP and sVCAM-1 levels between mild and severe (P < 0.05). There was no difference in the mean sVCAM-1 between normal pregnant and mild preeclamptic women. CONCLUSION: We have determined the serum concentration of VCAM-1 and hsCRP in normal pregnancy and preeclampsia. sVCAM-1 is elevated in severe preeclampsia compared with normal pregnancy, and hsCRP is elevated in severe preeclampsia compared with mild preeclampsia and normal pregnancy.
BACKGROUND: Preeclampsia is characterized by hypertension, dyslipidemia, and systemic inflammatory response. The aim of this study was to determine the level of serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1) and high-sensitive C-reactive protein (hsCRP) in preeclampsia and to compare normal pregnant, mild preeclamptic, and severe preeclamptic women. METHODS: A cross-sectional study was conducted to determine the plasma concentrations of sVCAM-1 and hsCRP in peripheral blood obtained from normal pregnant (n = 40), mild preeclamptic (n = 37), and severe preeclamptic women (n = 38). A concentration of soluble adhesion molecule was determined with enzyme-linked immunosorbent assay. hsCRP was measured with immunoturbidometric. RESULTS: There was significant difference in the means serum hsCRP between normal pregnant women and mild preeclamptic women (P < 0.05). Serum concentration of hsCRP and sVCAM-1 (ng/mL) were significantly higher in severe preeclampsia (P < 0.05) than normal pregnancy. There were also significant differences in hsCRP and sVCAM-1 levels between mild and severe (P < 0.05). There was no difference in the mean sVCAM-1 between normal pregnant and mild preeclamptic women. CONCLUSION: We have determined the serum concentration of VCAM-1 and hsCRP in normal pregnancy and preeclampsia. sVCAM-1 is elevated in severe preeclampsia compared with normal pregnancy, and hsCRP is elevated in severe preeclampsia compared with mild preeclampsia and normal pregnancy.
Entities:
Keywords:
high-sensitive C-reactive protein (hsCRP); normal pregnancies; preeclampsia; soluble vascular cell adhesion molecule-1 (sVCAM-1); systemic inflammatory response
Authors: M L Tjoa; J M G van Vugt; A T J J Go; M A Blankenstein; C B M Oudejans; I J van Wijk Journal: J Reprod Immunol Date: 2003-06 Impact factor: 4.054
Authors: Dávid Ágoston Kovács; László Szabó; Katalin Jenei; Roland Fedor; Gergely Zádori; Lajos Zsom; Krisztina Kabai; Anita Záhonyi; László Asztalos; Balázs Nemes Journal: Interv Med Appl Sci Date: 2015-12
Authors: Luiza O Perucci; Fernanda S Carneiro; Cláudia N Ferreira; Michelle A Sugimoto; Frederico M Soriani; Gustavo G Martins; Kátia M Lima; Flávia L Guimarães; Antônio L Teixeira; Luci M Dusse; Karina B Gomes; Lirlândia P Sousa Journal: PLoS One Date: 2015-09-23 Impact factor: 3.240