OBJECTIVE: To investigate whether a maternal inflammatory response precedes the development of preeclampsia. DESIGN: Cross-sectional study. SETTING: Antenatal clinic in an inner city teaching hospital. POPULATION: Two groups of women were examined at 23-25 weeks of gestation. The first group (45 women) had normal uterine artery Doppler waveforms and subsequently had a normal pregnancy outcome. The second group (45 women) had Doppler evidence of impaired placental perfusion and 21 (47%) of them had normal outcome, 14 (31%) developed intrauterine growth restriction and 10 (22%) developed pre-eclampsia, with or without intrauterine growth restriction. METHODS: C-reactive protein, an acute-phase reactant, was measured in maternal serum using a highly sensitive method with a detection limit of 0.05 mg/L. MAIN OUTCOME MEASURES: Development of pre-eclampsia, as defined by the International Society for the Study of Hypertension in Pregnancy. Intrauterine growth restriction was defined as birthweight <5th centile for gestation and sex of the neonate. RESULTS: The serum C-reactive protein concentration in women who subsequently developed pre-eclampsia (median 1.56, range 0.55-3.12 mg/L) or delivered a baby with birthweight <5th centile (median 0.74, range 0.64-1.58 mg/L) was not significantly different from that in women with uncomplicated pregnancies (median 1.28, range 0.75-2.08 mg/L; P = 0.95 and P = 0.62, respectively). CONCLUSION: These findings suggest that the onset of clinical signs of pre-eclampsia may not be preceded by a maternal inflammatory response, as assessed by measurement of C-reactive protein.
OBJECTIVE: To investigate whether a maternal inflammatory response precedes the development of preeclampsia. DESIGN: Cross-sectional study. SETTING: Antenatal clinic in an inner city teaching hospital. POPULATION: Two groups of women were examined at 23-25 weeks of gestation. The first group (45 women) had normal uterine artery Doppler waveforms and subsequently had a normal pregnancy outcome. The second group (45 women) had Doppler evidence of impaired placental perfusion and 21 (47%) of them had normal outcome, 14 (31%) developed intrauterine growth restriction and 10 (22%) developed pre-eclampsia, with or without intrauterine growth restriction. METHODS:C-reactive protein, an acute-phase reactant, was measured in maternal serum using a highly sensitive method with a detection limit of 0.05 mg/L. MAIN OUTCOME MEASURES: Development of pre-eclampsia, as defined by the International Society for the Study of Hypertension in Pregnancy. Intrauterine growth restriction was defined as birthweight <5th centile for gestation and sex of the neonate. RESULTS: The serum C-reactive protein concentration in women who subsequently developed pre-eclampsia (median 1.56, range 0.55-3.12 mg/L) or delivered a baby with birthweight <5th centile (median 0.74, range 0.64-1.58 mg/L) was not significantly different from that in women with uncomplicated pregnancies (median 1.28, range 0.75-2.08 mg/L; P = 0.95 and P = 0.62, respectively). CONCLUSION: These findings suggest that the onset of clinical signs of pre-eclampsia may not be preceded by a maternal inflammatory response, as assessed by measurement of C-reactive protein.
Authors: Kelly K Ferguson; Elizabeth M Kamai; David E Cantonwine; Bhramar Mukherjee; John D Meeker; Thomas F McElrath Journal: Am J Reprod Immunol Date: 2018-07-08 Impact factor: 3.886
Authors: Hilary S Gammill; Robert W Powers; Rebecca G Clifton; J Peter Van Dorsten; Mark A Klebanoff; Marshall D Lindheimer; Baha Sibai; Mark B Landon; Menachem Miodovnik; Mitchell Dombrowski Journal: Hypertens Pregnancy Date: 2010 Impact factor: 2.108
Authors: Anaelechi J Onuegbu; Japhet M Olisekodiaka; John U Udo; Osita Umeononihu; Ubuoh K Amah; John E Okwara; Chidiadi Atuegbu Journal: Med Princ Pract Date: 2015-04-21 Impact factor: 1.927