OBJECTIVE: To investigate the relationship between the serum concentration of high mobility group box 1 protein (HMGB1) and oxidative stress in patients with atrial fibrillation (AF). METHODS: Patients with AF (paroxysmal or persistent) and matched control subjects were recruited. Serum HMGB1 concentration and malondialdehyde (MDA) and superoxide dismutase (SOD) activity were determined. RESULTS: Serum hs-CRP and HMGB1 concentrations and MDA activity were significantly higher in patients with persistent AF (n = 33) or paroxysmal AF (n = 53) than in controls (n = 30). Serum SOD activity was significantly lower in both patient groups than in controls. In the patient group, HMGB1 concentration was significantly positively correlated with MDA activity (r = 0.535), and negatively correlated with SOD activity (r = -0.491). MDA, SOD, hs-CRP and HMGB1 were significant independent predictors of AF. CONCLUSIONS: Increased oxidative stress may contribute to increased HMGB1 concentrations in patients with AF. Inhibition of oxidative stress may provide a potential therapeutic strategy for AF.
OBJECTIVE: To investigate the relationship between the serum concentration of high mobility group box 1 protein (HMGB1) and oxidative stress in patients with atrial fibrillation (AF). METHODS:Patients with AF (paroxysmal or persistent) and matched control subjects were recruited. Serum HMGB1 concentration and malondialdehyde (MDA) and superoxide dismutase (SOD) activity were determined. RESULTS: Serum hs-CRP and HMGB1 concentrations and MDA activity were significantly higher in patients with persistent AF (n = 33) or paroxysmal AF (n = 53) than in controls (n = 30). Serum SOD activity was significantly lower in both patient groups than in controls. In the patient group, HMGB1 concentration was significantly positively correlated with MDA activity (r = 0.535), and negatively correlated with SOD activity (r = -0.491). MDA, SOD, hs-CRP and HMGB1 were significant independent predictors of AF. CONCLUSIONS: Increased oxidative stress may contribute to increased HMGB1 concentrations in patients with AF. Inhibition of oxidative stress may provide a potential therapeutic strategy for AF.
Entities:
Keywords:
High mobility group box 1 protein; atrial fibrillation; inflammation; oxidative stress
Authors: Ghulam Mohammad; Kaiser Alam; Mohammad Imtiaz Nawaz; Mohammad Mairaj Siddiquei; Ahmed Mousa; Ahmed M Abu El-Asrar Journal: J Physiol Biochem Date: 2015-06-04 Impact factor: 4.158
Authors: John H Rosenberg; John H Werner; Gilman D Plitt; Victoria V Noble; Jordan T Spring; Brooke A Stephens; Aleem Siddique; Helenmari L Merritt-Genore; Michael J Moulton; Devendra K Agrawal Journal: Expert Rev Cardiovasc Ther Date: 2018-12-29