Literature DB >> 24262199

Blood-based biomarkers for Parkinson's disease.

Lama M Chahine1, Matthew B Stern, Alice Chen-Plotkin.   

Abstract

There is a pressing need for biomarkers to diagnose Parkinson's disease (PD), assess disease severity, and prognosticate course. Various types of biologic specimens are potential candidates for identifying biomarkers--defined here as surrogate indicators of physiological or pathophysiological states--but blood has the advantage of being minimally invasive to obtain. There are, however, several challenges to identifying biomarkers in blood. Several candidate biomarkers identified in other diseases or in other types of biological fluids are being pursued as blood-based biomarkers in PD. In addition, unbiased discovery is underway using techniques including metabolomics, proteomics, and gene expression profiling. In this review, we summarize these techniques and discuss the challenges and successes of blood-based biomarker discovery in PD. Blood-based biomarkers that are discussed include α-synuclein, DJ-1, uric acid, epidermal growth factor, apolipoprotein-A1, and peripheral inflammatory markers.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Blood-based biomarkers; Metabolomics; Parkinson's disease; Proteomics

Mesh：

Substances：

Year:  2014        PMID： 24262199      PMCID： PMC4070332          DOI： 10.1016/S1353-8020(13)70025-7

Source DB:  PubMed          Journal:  Parkinsonism Relat Disord        ISSN： 1353-8020            Impact factor:   4.891


  29 in total

1.  Molecular markers of early Parkinson's disease based on gene expression in blood.

Authors:  Clemens R Scherzer; Aron C Eklund; Lee J Morse; Zhixiang Liao; Joseph J Locascio; Daniel Fefer; Michael A Schwarzschild; Michael G Schlossmacher; Michael A Hauser; Jeffery M Vance; Lewis R Sudarsky; David G Standaert; John H Growdon; Roderick V Jensen; Steven R Gullans
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-10       Impact factor: 11.205

2.  The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service.

Authors:  Andrew J Hughes; Susan E Daniel; Yoav Ben-Shlomo; Andrew J Lees
Journal:  Brain       Date:  2002-04       Impact factor: 13.501

3.  Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

Authors:  M H Polymeropoulos; C Lavedan; E Leroy; S E Ide; A Dehejia; A Dutra; B Pike; H Root; J Rubenstein; R Boyer; E S Stenroos; S Chandrasekharappa; A Athanassiadou; T Papapetropoulos; W G Johnson; A M Lazzarini; R C Duvoisin; G Di Iorio; L I Golbe; R L Nussbaum
Journal:  Science       Date:  1997-06-27       Impact factor: 47.728

4.  Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.

Authors:  Omar M A El-Agnaf; Sultan A Salem; Katerina E Paleologou; Martin D Curran; Mark J Gibson; Jennifer A Court; Michael G Schlossmacher; David Allsop
Journal:  FASEB J       Date:  2006-03       Impact factor: 5.191

5.  Observations on serum uric acid levels and the risk of idiopathic Parkinson's disease.

Authors:  J W Davis; A Grandinetti; C I Waslien; G W Ross; L R White; D M Morens
Journal:  Am J Epidemiol       Date:  1996-09-01       Impact factor: 4.897

6.  Serum uric acid levels and the risk of Parkinson disease.

Authors:  Lonneke M L de Lau; Peter J Koudstaal; Albert Hofman; Monique M B Breteler
Journal:  Ann Neurol       Date:  2005-11       Impact factor: 10.422

Review 7.  Inflammation and neurodegeneration in Parkinson's disease.

Authors:  Patrick L McGeer; Edith G McGeer
Journal:  Parkinsonism Relat Disord       Date:  2004-05       Impact factor: 4.891

8.  Peripheral inflammatory biomarkers and risk of Parkinson's disease.

Authors:  Honglei Chen; Eilis J O'Reilly; Michael A Schwarzschild; Alberto Ascherio
Journal:  Am J Epidemiol       Date:  2007-09-22       Impact factor: 4.897

9.  Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.

Authors:  Vincenzo Bonifati; Patrizia Rizzu; Marijke J van Baren; Onno Schaap; Guido J Breedveld; Elmar Krieger; Marieke C J Dekker; Ferdinando Squitieri; Pablo Ibanez; Marijke Joosse; Jeroen W van Dongen; Nicola Vanacore; John C van Swieten; Alexis Brice; Giuseppe Meco; Cornelia M van Duijn; Ben A Oostra; Peter Heutink
Journal:  Science       Date:  2002-11-21       Impact factor: 47.728

10.  Plasma urate and risk of Parkinson's disease.

Authors:  M G Weisskopf; E O'Reilly; H Chen; M A Schwarzschild; A Ascherio
Journal:  Am J Epidemiol       Date:  2007-06-20       Impact factor: 4.897
View more
  40 in total

Review 1.  Advances in Biomarker Research in Parkinson's Disease.

Authors:  Shyamal H Mehta; Charles H Adler
Journal:  Curr Neurol Neurosci Rep       Date:  2016-01       Impact factor: 5.081

2.  Analysis of blood-based gene expression in idiopathic Parkinson disease.

Authors:  Ron Shamir; Christine Klein; David Amar; Eva-Juliane Vollstedt; Michael Bonin; Marija Usenovic; Yvette C Wong; Ales Maver; Sven Poths; Hershel Safer; Jean-Christophe Corvol; Suzanne Lesage; Ofer Lavi; Günther Deuschl; Gregor Kuhlenbaeumer; Heike Pawlack; Igor Ulitsky; Meike Kasten; Olaf Riess; Alexis Brice; Borut Peterlin; Dimitri Krainc
Journal:  Neurology       Date:  2017-09-15       Impact factor: 9.910

Review 3.  Unbiased approaches to biomarker discovery in neurodegenerative diseases.

Authors:  Alice S Chen-Plotkin
Journal:  Neuron       Date:  2014-11-05       Impact factor: 17.173

4.  Diagnosis and Drug Prediction of Parkinson's Disease Based on Immune-Related Genes.

Authors:  Jinglei Bao; Wansheng Chang; Yanjun Zhao
Journal:  J Mol Neurosci       Date:  2022-06-22       Impact factor: 2.866

5.  Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Authors:  Joseph J Locascio; Shirley Eberly; Zhixiang Liao; Ganqiang Liu; Ashley N Hoesing; Karen Duong; Ana Trisini-Lipsanopoulos; Kaltra Dhima; Albert Y Hung; Alice W Flaherty; Michael A Schwarzschild; Michael T Hayes; Anne-Marie Wills; U Shivraj Sohur; Nicte I Mejia; Dennis J Selkoe; David Oakes; Ira Shoulson; Xianjun Dong; Ken Marek; Bin Zheng; Adrian Ivinson; Bradley T Hyman; John H Growdon; Lewis R Sudarsky; Michael G Schlossmacher; Bernard Ravina; Clemens R Scherzer
Journal:  Brain       Date:  2015-07-28       Impact factor: 13.501

6.  Parkinson's Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis.

Authors:  George DeMaagd; Ashok Philip
Journal:  P T       Date:  2015-08

Review 7.  Characterizing Premotor Parkinson's Disease: Clinical Features and Objective Markers.

Authors:  Lama M Chahine; Matthew B Stern
Journal:  Mov Disord Clin Pract       Date:  2014-07-08

8.  Robust Dopaminergic Differentiation and Enhanced LPS-Induced Neuroinflammatory Response in Serum-Deprived Human SH-SY5Y Cells: Implication for Parkinson's Disease.

Authors:  Aram Niaz; Jocelyn Karunia; Mawj Mandwie; Kevin A Keay; Giuseppe Musumeci; Ghaith Al-Badri; Alessandro Castorina
Journal:  J Mol Neurosci       Date:  2020-08-13       Impact factor: 3.444

Review 9.  Pursuing Multiple Biomarkers for Early Idiopathic Parkinson's Disease Diagnosis.

Authors:  Yareth Gopar-Cuevas; Ana P Duarte-Jurado; Rosa N Diaz-Perez; Odila Saucedo-Cardenas; Maria J Loera-Arias; Roberto Montes-de-Oca-Luna; Humberto Rodriguez-Rocha; Aracely Garcia-Garcia
Journal:  Mol Neurobiol       Date:  2021-08-05       Impact factor: 5.590

10.  Validation of serum apolipoprotein A1 in rabies virus-infected mice as a biomarker for the preclinical diagnosis of rabies.

Authors:  Kentaro Yamada; Koji Kuribayashi; Naotaka Inomata; Kazuko Noguchi; Kazunori Kimitsuki; Catalino S Demetria; Nobuo Saito; Satoshi Inoue; Chun-Ho Park; Ryo Kaimori; Motoi Suzuki; Mariko Saito-Obata; Yasuhiko Kamiya; Daria L Manalo; Beatriz P Quiambao; Akira Nishizono
Journal:  Microbiol Immunol       Date:  2021-08-03       Impact factor: 2.962
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.