Literature DB >> 16240356

Serum uric acid levels and the risk of Parkinson disease.

Lonneke M L de Lau1, Peter J Koudstaal, Albert Hofman, Monique M B Breteler.   

Abstract

In a prospective population-based cohort study among 4,695 participants aged 55 years and older, with repeated in-person examination and on average 9.4 years of follow-up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51-0.98]), with evidence for a dose-effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 16240356     DOI： 10.1002/ana.20663

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  121 in total

1.  Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression.

Authors:  Robert Küffner; Neta Zach; Raquel Norel; Johann Hawe; David Schoenfeld; Liuxia Wang; Guang Li; Lilly Fang; Lester Mackey; Orla Hardiman; Merit Cudkowicz; Alexander Sherman; Gokhan Ertaylan; Moritz Grosse-Wentrup; Torsten Hothorn; Jules van Ligtenberg; Jakob H Macke; Timm Meyer; Bernhard Schölkopf; Linh Tran; Rubio Vaughan; Gustavo Stolovitzky; Melanie L Leitner
Journal:  Nat Biotechnol       Date:  2014-11-02       Impact factor: 54.908

Review 2.  Gout, hyperuricemia, and Parkinson's disease: a protective effect?

Authors:  Alvaro Alonso; Kelly A Sovell
Journal:  Curr Rheumatol Rep       Date:  2010-04       Impact factor: 4.592

Review 3.  Advances in Biomarker Research in Parkinson's Disease.

Authors:  Shyamal H Mehta; Charles H Adler
Journal:  Curr Neurol Neurosci Rep       Date:  2016-01       Impact factor: 5.081

4.  Recreational physical activity and risk of Parkinson's disease.

Authors:  Evan L Thacker; Honglei Chen; Alpa V Patel; Marjorie L McCullough; Eugenia E Calle; Michael J Thun; Michael A Schwarzschild; Alberto Ascherio
Journal:  Mov Disord       Date:  2008-01       Impact factor: 10.338

5.  Prospective study of dietary pattern and risk of Parkinson disease.

Authors:  Xiang Gao; Honglei Chen; Teresa T Fung; Giancarlo Logroscino; Michael A Schwarzschild; Frank B Hu; Alberto Ascherio
Journal:  Am J Clin Nutr       Date:  2007-11       Impact factor: 7.045

6.  Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease.

Authors:  Kelly Claire Simon; Honglei Chen; Michael Schwarzschild; Alberto Ascherio
Journal:  Neurology       Date:  2007-08-29       Impact factor: 9.910

Review 7.  Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

Authors:  Weidong Le; Jie Dong; Song Li; Amos D Korczyn
Journal:  Neurosci Bull       Date:  2017-09-02       Impact factor: 5.203

8.  Novel allelic variants and evidence for a prevalent mutation in URAT1 causing renal hypouricemia: biochemical, genetics and functional analysis.

Authors:  Blanka Stiburkova; Ivan Sebesta; Kimiyoshi Ichida; Makiko Nakamura; Helena Hulkova; Vladimir Krylov; Lenka Kryspinova; Helena Jahnova
Journal:  Eur J Hum Genet       Date:  2013-02-06       Impact factor: 4.246

9.  Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study.

Authors:  Honglei Chen; Thomas H Mosley; Alvaro Alonso; Xuemei Huang
Journal:  Am J Epidemiol       Date:  2009-03-18       Impact factor: 4.897

10.  Gout and the risk of Parkinson's disease in Denmark.

Authors:  Eva Schernhammer; Jiaheng Qiu; Lene Wermuth; Christina Funch Lassen; Soren Friis; Beate Ritz
Journal:  Eur J Epidemiol       Date:  2013-03-02       Impact factor: 8.082
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.