Literature DB >> 24255982

One-pot three-component approach to the synthesis of polyfunctional pyrazoles.

Guolin Zhang1, Hangcheng Ni, Wenteng Chen, Jiaan Shao, Huan Liu, Binhui Chen, Yongping Yu.   

Abstract

A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.

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Year:  2013        PMID： 24255982     DOI： 10.1021/ol402810f

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

Review 1.  Reactivities of vinyl azides and their recent applications in nitrogen heterocycle synthesis.

Authors:  Bao Hu; Stephen G DiMagno
Journal:  Org Biomol Chem       Date:  2015-04-07       Impact factor: 3.876

Review 2.  Vinylazides: versatile synthons and magical precursors for the construction of N-heterocycles.

Authors:  Zahra Tashrifi; Mohammad Mohammadi-Khanaposhtani; Bagher Larijani; Halleh Hamedifar; Samira Ansari; Mohammad Mahdavi
Journal:  Mol Divers       Date:  2020-05-30       Impact factor: 2.943

3.  Metal-free C-H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation.

Authors:  Jennifer K Matsui; David N Primer; Gary A Molander
Journal:  Chem Sci       Date:  2017-03-06       Impact factor: 9.825

4.  An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity.

Authors:  Fariba Peytam; Mehdi Adib; Reihaneh Shourgeshty; Loghman Firoozpour; Mahmoud Rahmanian-Jazi; Mehdi Jahani; Setareh Moghimi; Kouros Divsalar; Mohammad Ali Faramarzi; Somayeh Mojtabavi; Fatemeh Safari; Mohammad Mahdavi; Alireza Foroumadi
Journal:  Sci Rep       Date:  2020-02-13       Impact factor: 4.379

Review 5.  Pyrazole Scaffold Synthesis, Functionalization, and Applications in Alzheimer's Disease and Parkinson's Disease Treatment (2011-2020).

Authors:  Xuefei Li; Yanbo Yu; Zhude Tu
Journal:  Molecules       Date:  2021-02-24       Impact factor: 4.411

6.  Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase.

Authors:  Fariba Peytam; Ghazaleh Takalloobanafshi; Toktam Saadattalab; Maryam Norouzbahari; Zahra Emamgholipour; Setareh Moghimi; Loghman Firoozpour; Hamid Reza Bijanzadeh; Mohammad Ali Faramarzi; Somayeh Mojtabavi; Parviz Rashidi-Ranjbar; Saeed Karima; Roya Pakraad; Alireza Foroumadi
Journal:  Sci Rep       Date:  2021-06-07       Impact factor: 4.379
  6 in total

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