Literature DB >> 2425598

Characteristics of the effect of phorbol ester on rat mast cells: interaction with anti-IgE.

M E Cantwell, J C Foreman.   

Abstract

The phorbol ester 12-0-tetradecanoyl-13-acetate (TPA) induced a dose-dependent release of histamine from rat peritoneal mast cells at concentrations from 3 to 100 ng/ml. The release is biphasic: an early phase being complete in 15 min and being followed by a second phase extending for more than 50 min. Concentrations of TPA greater than 100 ng/ml produced decreasing releases of histamine. Synergistic interaction in the induction of histamine secretion was observed between TPA and A23187 and between TPA and anti-IgE. Such synergism with anti-IgE was only manifest at low concentrations of TPA and with incubations of the cells with TPA for 5 mins or less. At higher concentrations of TPA and longer incubations, TPA inhibited the response of rat peritoneal mast cells to anti-IgE stimulation. Synergism between A23187 and TPA was observed only at low levels of histamine release induced by calcium plus A23187: at higher levels of release TPA was inhibitory.

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Year:  1986        PMID： 2425598     DOI： 10.1007/bf01987988

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  Induction of calcium flux across the rat mast cell membrane by bridging IgE receptors.

Authors:  T Ishizaka; J C Foreman; A R Sterk; K Ishizaka
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

2.  Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells.

Authors:  R Sagi-Eisenberg; H Lieman; I Pecht
Journal:  Nature       Date:  1985 Jan 3-9       Impact factor: 49.962

3.  Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

Authors:  J F Kuo; R G Andersson; B C Wise; L Mackerlova; I Salomonsson; N L Brackett; N Katoh; M Shoji; R W Wrenn
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

4.  Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors:  M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

5.  Phorbol ester-induced protein secretion in rat parotid gland. Relationship to the role of inositol lipid breakdown and protein kinase C activation in stimulus-secretion coupling.

Authors:  J W Putney; J S McKinney; D L Aub; B A Leslie
Journal:  Mol Pharmacol       Date:  1984-09       Impact factor: 4.436

6.  Histamine release induced by histone and phorbol ester from rat peritoneal mast cells.

Authors:  R Sagi-Eisenberg; J C Foreman; R Shelly
Journal:  Eur J Pharmacol       Date:  1985-07-11       Impact factor: 4.432

Review 7.  Inositol trisphosphate, a novel second messenger in cellular signal transduction.

Authors:  M J Berridge; R F Irvine
Journal:  Nature       Date:  1984 Nov 22-28       Impact factor: 49.962

8.  Protein kinase C, a coupling element between stimulus and secretion of basophils.

Authors:  R Sagi-Eisenberg; I Pecht
Journal:  Immunol Lett       Date:  1984       Impact factor: 3.685

9.  Evidence for a role of phosphatidylinositol turnover in stimulus-secretion coupling. Studies with rat peritoneal mast cells.

Authors:  S Cockcroft; B D Gomperts
Journal:  Biochem J       Date:  1979-03-15       Impact factor: 3.857

10.  Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells.

Authors:  Y Katakami; K Kaibuchi; M Sawamura; Y Takai; Y Nishizuka
Journal:  Biochem Biophys Res Commun       Date:  1984-06-15       Impact factor: 3.575
  10 in total
  8 in total

1.  The actions of inhibitors of diacylglycerol kinase and diacylglycerol lipase on histamine release from rat peritoneal mast cells.

Authors:  M E Cantwell; J C Foreman
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

2.  Phorbol esters induce a slow, non-cytotoxic release of histamine from rat peritoneal mast cells.

Authors:  M E Cantwell; J C Foreman
Journal:  Agents Actions       Date:  1987-04

3.  Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on substance P-induced histamine release from rat peritoneal mast cells.

Authors:  J McLeod; N A Hayes; J C Foreman
Journal:  Agents Actions       Date:  1990-04

4.  The effects of the protein kinase C inhibitors staurosporine and H7 on the IgE dependent mediator release from RBL 2H3 cells.

Authors:  A M Gilfillan; G A Wiggan; A F Welton
Journal:  Agents Actions       Date:  1990-06

5.  Role of mast cells in plasma permeation due to immune injury of the skin basement membrane.

Authors:  Y Zhang; B F Ramos; B A Jakschik
Journal:  Immunology       Date:  1992-11       Impact factor: 7.397

6.  Pharmacological investigations with different protein kinase C inhibitors on IgE-dependent and IgE-independent activation of human basophils.

Authors:  U Amon; E von Stebut; H H Wolff
Journal:  Agents Actions       Date:  1993-05

7.  The influence of tetradecanoyl-phorbol-acetate (TPA) on histamine release from isolated rat mast cells.

Authors:  N Grosman; K A Nielsen
Journal:  Agents Actions       Date:  1988-06

8.  Effects of phorbol ester, serine phospholipids, and calcium on histamine release from mast cells and basophils.

Authors:  T M Cunniffe; F L Pearce
Journal:  Agents Actions       Date:  1988-04
  8 in total

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