Literature DB >> 24255585

Imatinib mesylate in clinically suspected gastric stromal tumors.

Zi-Yu Li1, Lei Tang, Shuang-Xi Li, Fei Shan, Zhao-De Bu, Jia-Fu Ji.   

Abstract

Gastrointestinal stromal tumors (GISTs) occur most frequently in the stomach. Diagnosis of gastric GIST is not always clear before surgery. Flexible endoscopy may suggest the nature of the lesion (a bulky tumor with preserved mucosa); however, biopsy is rarely diagnostic. Therefore, diagnostic medication with safe drugs may provide a feasible way under such conditions after an informed consent is obtained. Based on the excellent efficacy of imatinib mesylate (IM) in the treatment of GIST, we successfully applied it in the diagnostic medication of two patients with clinically suspected gastric stromal tumors. In conclusion, the diagnostic medication with IM can be an alternative option for patients with suspected GIST that can not be confirmed pathologically.

Entities:  

Keywords:  Gastrointestinal stromal tumors (GISTs); imatinib mesylate (IM); magnetic resonance imaging (MRI)

Year:  2013        PMID： 24255585      PMCID： PMC3828431          DOI： 10.3978/j.issn.1000-9604.2013.10.14

Source DB:  PubMed          Journal:  Chin J Cancer Res        ISSN： 1000-9604            Impact factor:   5.087


  5 in total

1.  Gastrointestinal stromal tumors treated with imatinib mesylate: apparent diffusion coefficient in the evaluation of therapy response in patients.

Authors:  Lei Tang; Xiao-Peng Zhang; Ying-Shi Sun; Lin Shen; Jian Li; Li-Ping Qi; Yong Cui
Journal:  Radiology       Date:  2010-12-30       Impact factor: 11.105

2.  Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria.

Authors:  Haesun Choi; Chuslip Charnsangavej; Silvana C Faria; Homer A Macapinlac; Michael A Burgess; Shreyaskumar R Patel; Lei L Chen; Donald A Podoloff; Robert S Benjamin
Journal:  J Clin Oncol       Date:  2007-05-01       Impact factor: 44.544

Review 3.  Diagnosis of gastrointestinal stromal tumors: A consensus approach.

Authors:  Christopher D M Fletcher; Jules J Berman; Christopher Corless; Fred Gorstein; Jerzy Lasota; B Jack Longley; Markku Miettinen; Timothy J O'Leary; Helen Remotti; Brian P Rubin; Barry Shmookler; Leslie H Sobin; Sharon W Weiss
Journal:  Hum Pathol       Date:  2002-05       Impact factor: 3.466

4.  Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665.

Authors:  Burton L Eisenberg; Jonathan Harris; Charles D Blanke; George D Demetri; Michael C Heinrich; James C Watson; John P Hoffman; Scott Okuno; John M Kane; Margaret von Mehren
Journal:  J Surg Oncol       Date:  2009-01-01       Impact factor: 3.454

5.  Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.

Authors:  George D Demetri; Margaret von Mehren; Charles D Blanke; Annick D Van den Abbeele; Burton Eisenberg; Peter J Roberts; Michael C Heinrich; David A Tuveson; Samuel Singer; Milos Janicek; Jonathan A Fletcher; Stuart G Silverman; Sandra L Silberman; Renaud Capdeville; Beate Kiese; Bin Peng; Sasa Dimitrijevic; Brian J Druker; Christopher Corless; Christopher D M Fletcher; Heikki Joensuu
Journal:  N Engl J Med       Date:  2002-08-15       Impact factor: 91.245
  5 in total
  4 in total

1.  Altered expression profile of micrornas in gastric stromal tumor.

Authors:  Jun Xiao; Qi-Xian Wang; You-Qing Zhu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2015-12-16

2.  MicroRNA-218 inhibits gastrointestinal stromal tumor cell and invasion by targeting KIT.

Authors:  Rong Fan; Jie Zhong; Sichang Zheng; Zhengting Wang; Ying Xu; Shuyi Li; Jie Zhou; Fei Yuan
Journal:  Tumour Biol       Date:  2013-12-29

3.  Identifying and validating a combined mRNA and microRNA signature in response to imatinib treatment in a chronic myeloid leukemia cell line.

Authors:  Steven Bhutra; Divya Lenkala; Bonnie LaCroix; Meng Ye; R Stephanie Huang
Journal:  PLoS One       Date:  2014-12-15       Impact factor: 3.240

Review 4.  The efficacy and safety of laparoscopy combined with gastroscopy positioning in treating gastric stromal tumours: A systematic review and meta-analysis.

Authors:  Hu Zhang; Jie Chen; Chen Chen
Journal:  J Minim Access Surg       Date:  2021 Apr-Jun       Impact factor: 1.407
  4 in total

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