Antônio da Silva Novaes1, Jonas da Silva Mota2, Andersson Barison3, Clebson Luiz Veber3, Fábio Juliano Negrão1, Candida Aparecida Leite Kassuya1, Márcio Eduardo de Barros4. 1. Department of Health Sciences, Federal University of Grande Dourados, MS, Brazil. 2. Department of Biodiversity Research, University of the State of Mato Grosso do Sul, Dourados, MS, Brazil. 3. Department of Chemistry, Polytechnic Center, Federal University of Paraná Federal University, Curitiba, PR, Brazil. 4. Department of Health Sciences, Federal University of Grande Dourados, MS, Brazil; General Hospital, Federal University of Grande Dourados, MS, Brazil. Electronic address: marciobarros@ufgd.edu.br.
Abstract
OBJECTIVE: Piper amalago is used in Brazilian folk medicine as diuretic and for the treatment of urinary calculus disease, although no scientific data have been described to support these effects. Thus, this study aims to evaluate the diuretic effects and antilithiatic activity of the ethanolic extract of P. amalago (EEPam). MATERIALS AND METHODS: Ethanolic extracts of P. amalago (125, 250 and 500mg/kg) were orally administered in male Wistar rats (n=5) and urinary excretion was measured at intervals of up to 24h after administration. The antilithiasic effect of EEPam on calcium oxalate urolithiasis crystallization was examined in a turbidimetric model. RESULTS: The oral administration of all doses of EEPam significantly increased urine output after 24h when compared to control group. Moreover, the application of EEPam, induced an inhibitory effect on calcium oxalate crystallization. CONCLUSIONS: According to results, P. amalago extracts showed diuretic and natriuretic activity and antilithiasic effects.
OBJECTIVE:Piper amalago is used in Brazilian folk medicine as diuretic and for the treatment of urinary calculus disease, although no scientific data have been described to support these effects. Thus, this study aims to evaluate the diuretic effects and antilithiatic activity of the ethanolic extract of P. amalago (EEPam). MATERIALS AND METHODS: Ethanolic extracts of P. amalago (125, 250 and 500mg/kg) were orally administered in male Wistar rats (n=5) and urinary excretion was measured at intervals of up to 24h after administration. The antilithiasic effect of EEPam on calcium oxalateurolithiasis crystallization was examined in a turbidimetric model. RESULTS: The oral administration of all doses of EEPam significantly increased urine output after 24h when compared to control group. Moreover, the application of EEPam, induced an inhibitory effect on calcium oxalate crystallization. CONCLUSIONS: According to results, P. amalago extracts showed diuretic and natriuretic activity and antilithiasic effects.
Authors: V S Carrara; L C Filho; V A S Garcia; V S Faiões; E F Cunha-Júnior; E C Torres-Santos; D A G Cortez Journal: Evid Based Complement Alternat Med Date: 2017-05-02 Impact factor: 2.629