| Literature DB >> 23434029 |
Eunhee Chae1, Yong-Je Shin, Eun-Ju Ryu, Mi Kyung Ji, Nahm Ryune Cho, Ki-Ho Lee, Hyun Ji Jeong, Soo-Jin Kim, Yeonjung Choi, Kyung Seok Oh, Chun-Eung Park, Young Soo Yoon.
Abstract
Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinyl imidazoles series of mGlu5 receptor negative allosteric modulators (mGluR5 NAMs) using a functional cell-based assay is described in this Letter. Analysis of the Ligand-lipophilic efficiency (LipE) of compounds provided new insight for the design of potent mGluR5 negative allosteric modulators with anti-depressant activities.Entities:
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Year: 2013 PMID： 23434029 DOI： 10.1016/j.bmcl.2013.01.116
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823