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Literature DB >> 24247922

Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors.

Saskia A Bode¹, Rike Wallbrecher, Roland Brock, Jan C M van Hest, Dennis W P M Löwik.

Abstract

A small library of oligoarginine peptides equipped with terminal cysteines was studied with respect to their cell-penetrating properties. The peptides themselves were inactive but gained the ability to enter cells upon extension of their sequence through disulfide bridge formation.

Entities: Chemical

Mesh：

Substances：

Year: 2014 PMID： 24247922 DOI： 10.1039/c3cc46826g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

10 in total

1. Understanding Cell Penetration of Cyclic Peptides.

Authors: Patrick G Dougherty; Ashweta Sahni; Dehua Pei
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Journal: Bioconjug Chem Date: 2014-12-30 Impact factor: 4.774

3. Diselenolane-mediated cellular uptake.

Authors: Nicolas Chuard; Amalia I Poblador-Bahamonde; Lili Zong; Eline Bartolami; Jana Hildebrandt; Wolfgang Weigand; Naomi Sakai; Stefan Matile
Journal: Chem Sci Date: 2018-01-17 Impact factor: 9.825

4. Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks.

Authors: Javier López-Andarias; Jacques Saarbach; Dimitri Moreau; Yangyang Cheng; Emmanuel Derivery; Quentin Laurent; Marcos González-Gaitán; Nicolas Winssinger; Naomi Sakai; Stefan Matile
Journal: J Am Chem Soc Date: 2020-02-28 Impact factor: 15.419

Activation of cell-penetrating peptides by disulfide bridge formation of truncated precursors.

1. Understanding Cell Penetration of Cyclic Peptides.

2. Dual peptide conjugation strategy for improved cellular uptake and mitochondria targeting.

3. Diselenolane-mediated cellular uptake.

4. Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks.

Review 5. Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management.

Review 6. Novel Pharmaceutical Strategies for Enhancing Skin Penetration of Biomacromolecules.

7. The Dynamic Range of Acidity: Tracking Rules for the Unidirectional Penetration of Cellular Compartments.

Review 8. Cell-Penetrating Peptides: Design Strategies beyond Primary Structure and Amphipathicity.

9. Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides.

10. Activation of cell-penetrating peptide fragments by disulfide formation.