Literature DB >> 24243007

Stochastic fate selection in HIV-infected patients.

Ariel D Weinberger1, Leor S Weinberger.   

Abstract

Classic studies proposed that stochastic variability ("noise") can drive biological fate switching, enhancing evolutionary success. Now, Ho et al. report that HIV's reactivation from dormant (latently infected) patient cells-the major barrier to an HIV cure-is inherently stochastic. Eradicating an incompletely inducible (probabilistic) viral phenotype will require inventive approaches.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24243007     DOI： 10.1016/j.cell.2013.09.039

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  28 in total

Review 1.  Measuring the latent reservoir in vivo.

Authors:  Marta Massanella; Douglas D Richman
Journal:  J Clin Invest       Date:  2016-02-01       Impact factor: 14.808

2.  A hardwired HIV latency program.

Authors:  Brandon S Razooky; Anand Pai; Katherine Aull; Igor M Rouzine; Leor S Weinberger
Journal:  Cell       Date:  2015-02-26       Impact factor: 41.582

3.  Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen.

Authors:  Jessica A Linderman; Mariko Kobayashi; Vinayak Rayannavar; John J Fak; Robert B Darnell; Moses V Chao; Angus C Wilson; Ian Mohr
Journal:  Cell Rep       Date:  2017-01-31       Impact factor: 9.423

4.  A Stronger Transcription Regulatory Circuit of HIV-1C Drives the Rapid Establishment of Latency with Implications for the Direct Involvement of Tat.

Authors:  Sutanuka Chakraborty; Manisha Kabi; Udaykumar Ranga
Journal:  J Virol       Date:  2020-09-15       Impact factor: 5.103

Review 5.  Fate-Regulating Circuits in Viruses: From Discovery to New Therapy Targets.

Authors:  Anand Pai; Leor S Weinberger
Journal:  Annu Rev Virol       Date:  2017-08-11       Impact factor: 10.431

Review 6.  Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure.

Authors:  Uri Mbonye; Jonathan Karn
Journal:  Virology       Date:  2014-02-22       Impact factor: 3.616

7.  A passive-flow microfluidic device for imaging latent HIV activation dynamics in single T cells.

Authors:  Ramesh Ramji; Victor C Wong; Arvind K Chavali; Larisa M Gearhart; Kathryn Miller-Jensen
Journal:  Integr Biol (Camb)       Date:  2015-07-03       Impact factor: 2.192

8.  In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.

Authors:  Cari F Kessing; Christopher C Nixon; Chuan Li; Perry Tsai; Hiroshi Takata; Guillaume Mousseau; Phong T Ho; Jenna B Honeycutt; Mohammad Fallahi; Lydie Trautmann; J Victor Garcia; Susana T Valente
Journal:  Cell Rep       Date:  2017-10-17       Impact factor: 9.423

9.  Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.

Authors:  James M Hill; Debra C Quenelle; Rhonda D Cardin; Jodi L Vogel; Christian Clement; Fernando J Bravo; Timothy P Foster; Marta Bosch-Marce; Priya Raja; Jennifer S Lee; David I Bernstein; Philip R Krause; David M Knipe; Thomas M Kristie
Journal:  Sci Transl Med       Date:  2014-12-03       Impact factor: 17.956

10.  What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems.

Authors:  Prasanna M Bhogale; Robin A Sorg; Jan-Willem Veening; Johannes Berg
Journal:  Nucleic Acids Res       Date:  2014-09-22       Impact factor: 16.971
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