Literature DB >> 24241637

Network medicine in disease analysis and therapeutics.

B Chen1, A J Butte.   

Abstract

Two parallel trends are occurring in drug discovery. The first is that we are moving away from a symptom-based disease classification system to a system based on molecules and molecular states. The second is that we are shifting from targeting a single molecule toward targeting multiple molecules, pathways, or networks. Network medicine is an approach to understanding disease and discovering therapeutics looking at many molecules and how they interrelate, and it may play a critical role in the adoption of both trends.

Entities:  

Mesh:

Year:  2013        PMID: 24241637      PMCID: PMC5624966          DOI: 10.1038/clpt.2013.181

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  10 in total

1.  The human disease network.

Authors:  Kwang-Il Goh; Michael E Cusick; David Valle; Barton Childs; Marc Vidal; Albert-László Barabási
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-14       Impact factor: 11.205

Review 2.  Network pharmacology: the next paradigm in drug discovery.

Authors:  Andrew L Hopkins
Journal:  Nat Chem Biol       Date:  2008-11       Impact factor: 15.040

Review 3.  Network medicine: a network-based approach to human disease.

Authors:  Albert-László Barabási; Natali Gulbahce; Joseph Loscalzo
Journal:  Nat Rev Genet       Date:  2011-01       Impact factor: 53.242

4.  Discovery and preclinical validation of drug indications using compendia of public gene expression data.

Authors:  Marina Sirota; Joel T Dudley; Jeewon Kim; Annie P Chiang; Alex A Morgan; Alejandro Sweet-Cordero; Julien Sage; Atul J Butte
Journal:  Sci Transl Med       Date:  2011-08-17       Impact factor: 17.956

5.  Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets.

Authors:  Silpa Suthram; Joel T Dudley; Annie P Chiang; Rong Chen; Trevor J Hastie; Atul J Butte
Journal:  PLoS Comput Biol       Date:  2010-02-05       Impact factor: 4.475

6.  Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.

Authors:  Michael J Lee; Albert S Ye; Alexandra K Gardino; Anne Margriet Heijink; Peter K Sorger; Gavin MacBeath; Michael B Yaffe
Journal:  Cell       Date:  2012-05-11       Impact factor: 41.582

7.  Comprehensive molecular portraits of human breast tumours.

Authors: 
Journal:  Nature       Date:  2012-09-23       Impact factor: 49.962

8.  A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop.

Authors:  K E Ware; T K Hinz; E Kleczko; K R Singleton; L A Marek; B A Helfrich; C T Cummings; D K Graham; D Astling; A-C Tan; L E Heasley
Journal:  Oncogenesis       Date:  2013-03-25       Impact factor: 7.485

9.  Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.

Authors:  Murat Iskar; Georg Zeller; Peter Blattmann; Monica Campillos; Michael Kuhn; Katarzyna H Kaminska; Heiko Runz; Anne-Claude Gavin; Rainer Pepperkok; Vera van Noort; Peer Bork
Journal:  Mol Syst Biol       Date:  2013       Impact factor: 11.429

Review 10.  Key issues in conducting a meta-analysis of gene expression microarray datasets.

Authors:  Adaikalavan Ramasamy; Adrian Mondry; Chris C Holmes; Douglas G Altman
Journal:  PLoS Med       Date:  2008-09-02       Impact factor: 11.069

  10 in total
  18 in total

1.  A multiparametric organ toxicity predictor for drug discovery.

Authors:  Chirag N Patel; Sivakumar Prasanth Kumar; Rakesh M Rawal; Daxesh P Patel; Frank J Gonzalez; Himanshu A Pandya
Journal:  Toxicol Mech Methods       Date:  2019-10-29       Impact factor: 2.987

2.  Applying a "Big Data" Literature System to Recommend Antihypertensive Drugs for Hypertension Patients with Diabetes Mellitus.

Authors:  Jing-Xian Shu; Ying Li; Ting He; Ling Chen; Xue Li; Lin-Lin Zou; Lu Yin; Xiao-Hui Li; An-Li Wang; Xing Liu; Hong Yuan
Journal:  Med Sci Monit       Date:  2018-01-07

Review 3.  Diverse array-designed modes of combination therapies in Fangjiomics.

Authors:  Jun Liu; Zhong Wang
Journal:  Acta Pharmacol Sin       Date:  2015-04-13       Impact factor: 6.150

Review 4.  From gene networks to drugs: systems pharmacology approaches for AUD.

Authors:  Laura B Ferguson; R Adron Harris; Roy Dayne Mayfield
Journal:  Psychopharmacology (Berl)       Date:  2018-03-01       Impact factor: 4.530

Review 5.  Molecular networks in Network Medicine: Development and applications.

Authors:  Edwin K Silverman; Harald H H W Schmidt; Eleni Anastasiadou; Lucia Altucci; Marco Angelini; Lina Badimon; Jean-Luc Balligand; Giuditta Benincasa; Giovambattista Capasso; Federica Conte; Antonella Di Costanzo; Lorenzo Farina; Giulia Fiscon; Laurent Gatto; Michele Gentili; Joseph Loscalzo; Cinzia Marchese; Claudio Napoli; Paola Paci; Manuela Petti; John Quackenbush; Paolo Tieri; Davide Viggiano; Gemma Vilahur; Kimberly Glass; Jan Baumbach
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2020-04-19

6.  Characteristics of drug combination therapy in oncology by analyzing clinical trial data on ClinicalTrials.gov.

Authors:  Menghua Wu; Marina Sirota; Atul J Butte; Bin Chen
Journal:  Pac Symp Biocomput       Date:  2015

7.  Combinatorial Study of a Novel Poly (ADP-ribose) Polymerase Inhibitor and an HDAC Inhibitor, SAHA, in Leukemic Cell Lines.

Authors:  Mahesh Hegde; Kempegowda Mantelingu; Monica Pandey; Chottanahalli S Pavankumar; Kanchugarakoppal S Rangappa; Sathees C Raghavan
Journal:  Target Oncol       Date:  2016-10       Impact factor: 4.493

8.  Predicting high-throughput screening results with scalable literature-based discovery methods.

Authors:  T Cohen; D Widdows; C Stephan; R Zinner; J Kim; T Rindflesch; P Davies
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2014-10-08

Review 9.  Network representations of immune system complexity.

Authors:  Naeha Subramanian; Parizad Torabi-Parizi; Rachel A Gottschalk; Ronald N Germain; Bhaskar Dutta
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2015-01-27

Review 10.  Computational approaches in target identification and drug discovery.

Authors:  Theodora Katsila; Georgios A Spyroulias; George P Patrinos; Minos-Timotheos Matsoukas
Journal:  Comput Struct Biotechnol J       Date:  2016-05-07       Impact factor: 7.271

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