Literature DB >> 24239028

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

Jessica L Esseltine1, John D Scott.   

Abstract

A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling enzymes with their substrates. Great strides have been made in elucidating the role of these macromolecular signaling complexes as new binding partners and novel AKAPs are continually being uncovered. The mechanics and dynamics of these multi-enzyme assemblies suggest that AKAP complexes are viable targets for therapeutic intervention. This review will highlight recent advances in AKAP research focusing on local signaling events that are perturbed in disease.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  AKAP; Ca(2+); disease; interfering peptide; protein kinase; protein phosphatase; signal transduction

Mesh：

Substances：

Year:  2013        PMID： 24239028      PMCID： PMC3879114          DOI： 10.1016/j.tips.2013.10.005

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  78 in total

1.  Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

Authors:  Lianghui Zhang; Sundeep Malik; Jinjiang Pang; Huan Wang; Keigan M Park; David I Yule; Burns C Blaxall; Alan V Smrcka
Journal:  Cell       Date:  2013-03-28       Impact factor: 41.582

2.  Expression and humoral response of A-kinase anchor protein 4 in cervical cancer.

Authors:  Sumit Agarwal; Shikha Saini; Deepak Parashar; Archana Verma; Nirmala Jagadish; Aruna Batra; Sushma Suri; Amar Bhatnagar; Anju Gupta; Abdul S Ansari; Nirmal K Lohiya; Anil Suri
Journal:  Int J Gynecol Cancer       Date:  2013-05       Impact factor: 3.437

3.  A-kinase anchoring protein-calcineurin signaling in long-term depression of GABAergic synapses.

Authors:  Matthieu Dacher; Shawn Gouty; Steven Dash; Brian M Cox; Fereshteh S Nugent
Journal:  J Neurosci       Date:  2013-02-06       Impact factor: 6.167

4.  Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.

Authors:  Riad Efendiev; Alexis Bavencoffe; Hongzhen Hu; Michael X Zhu; Carmen W Dessauer
Journal:  J Biol Chem       Date:  2012-12-21       Impact factor: 5.157

5.  cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.

Authors:  Minchul Kim; Miju Kim; Seunghee Lee; Shinji Kuninaka; Hideyuki Saya; Ho Lee; Sookyung Lee; Dae-Sik Lim
Journal:  EMBO J       Date:  2013-05-03       Impact factor: 11.598

6.  AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy.

Authors:  Matthew J Spindler; Brian T Burmeister; Yu Huang; Edward C Hsiao; Nathan Salomonis; Mark J Scott; Deepak Srivastava; Graeme K Carnegie; Bruce R Conklin
Journal:  PLoS One       Date:  2013-04-26       Impact factor: 3.240

7.  Adhesion-mediated cytoskeletal remodeling is controlled by the direct scaffolding of Src from FAK complexes to lipid rafts by SSeCKS/AKAP12.

Authors:  B Su; L Gao; F Meng; L-W Guo; J Rothschild; I H Gelman
Journal:  Oncogene       Date:  2012-06-18       Impact factor: 9.867

8.  Mapping the binding site of TRPV1 on AKAP79: implications for inflammatory hyperalgesia.

Authors:  Joan Btesh; Michael J M Fischer; Katherine Stott; Peter A McNaughton
Journal:  J Neurosci       Date:  2013-05-22       Impact factor: 6.167

9.  Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia.

Authors:  Michael J M Fischer; Joan Btesh; Peter A McNaughton
Journal:  J Neurosci       Date:  2013-04-24       Impact factor: 6.167

10.  A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer.

Authors:  Shikha Saini; Nirmala Jagadish; Anju Gupta; Amar Bhatnagar; Anil Suri
Journal:  PLoS One       Date:  2013-02-22       Impact factor: 3.240
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  55 in total

1.  Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.

Authors:  Adam Beach; Vincent R Richard; Simon Bourque; Tatiana Boukh-Viner; Pavlo Kyryakov; Alejandra Gomez-Perez; Anthony Arlia-Ciommo; Rachel Feldman; Anna Leonov; Amanda Piano; Veronika Svistkova; Vladimir I Titorenko
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

Review 2.  When trafficking and signaling mix: How subcellular location shapes G protein-coupled receptor activation of heterotrimeric G proteins.

Authors:  Braden T Lobingier; Mark von Zastrow
Journal:  Traffic       Date:  2019-02       Impact factor: 6.215

Review 3.  Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve.

Authors:  Jie Zhang; Mark S Shapiro
Journal:  J Physiol       Date:  2015-03-11       Impact factor: 5.182

4.  Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.

Authors:  F Donelson Smith; Mitchell H Omar; Patrick J Nygren; Joseph Soughayer; Naoto Hoshi; Ho-Tak Lau; Calvin G Snyder; Tess C Branon; Debapriya Ghosh; Lorene K Langeberg; Alice Y Ting; Luis F Santana; Shao-En Ong; Manuel F Navedo; John D Scott
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-19       Impact factor: 11.205

5.  A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.

Authors:  Wilfred J Poppinga; Irene H Heijink; Laura J Holtzer; Philipp Skroblin; Enno Klussmann; Andrew J Halayko; Wim Timens; Harm Maarsingh; Martina Schmidt
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-01-30       Impact factor: 5.464

6.  The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.

Authors:  Alessandro Dema; Micha Friedemann Schröter; Ekaterina Perets; Philipp Skroblin; Marie Christine Moutty; Veronika Anita Deàk; Walter Birchmeier; Enno Klussmann
Journal:  J Biol Chem       Date:  2016-08-02       Impact factor: 5.157

Review 7.  Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.

Authors:  William G Robichaux; Xiaodong Cheng
Journal:  Physiol Rev       Date:  2018-04-01       Impact factor: 37.312

8.  Rapid affinity purification of intracellular organelles using a twin strep tag.

Authors:  Jian Xiong; Jingquan He; Wendy P Xie; Ezekiel Hinojosa; Chandra Shekar R Ambati; Nagireddy Putluri; Hyun-Eui Kim; Michael X Zhu; Guangwei Du
Journal:  J Cell Sci       Date:  2019-12-13       Impact factor: 5.285

9.  Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles.

Authors:  Paula J Bucko; Irvin Garcia; Ridhima Manocha; Akansha Bhat; Linda Wordeman; John D Scott
Journal:  J Biol Chem       Date:  2020-07-30       Impact factor: 5.157

10.  PKA-type I selective constrained peptide disruptors of AKAP complexes.

Authors:  Yuxiao Wang; Tienhuei G Ho; Eugen Franz; Jennifer S Hermann; F Donelson Smith; Heidi Hehnly; Jessica L Esseltine; Laura E Hanold; Mandi M Murph; Daniela Bertinetti; John D Scott; Friedrich W Herberg; Eileen J Kennedy
Journal:  ACS Chem Biol       Date:  2015-03-25       Impact factor: 5.100
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