Literature DB >> 24239016

Synthesis and antitumor-evaluation of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives.

Hai-Chuan Zhao1, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li, Li-Na Xuan, Peng Wang, Kai Zhang, Bao-Quan Chen.   

Abstract

A series of novel 1,3-selenazole-containing 1,3,4-thiadiazole derivatives bearing Schiff base moieties were synthesized and evaluated for their in vitro antiproliferative activities against human breast cancer cell MCF-7 and mouse lymphocyte leukemia cell L1210 by CCK-8 assay. The majority of the compounds showed better activity against MCF-7 cell, compared with lead compound PCS. In particular, compound 6c was the most potent compound with IC50 value of 4.02 μM.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  1,3,4-Thiadiazole derivatives; 1,3-Selenazole; Antitumor agents; Schiff base

Mesh：

Substances：

Year:  2013        PMID： 24239016     DOI： 10.1016/j.bmcl.2013.10.062

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Dimroth rearrangement-based synthesis of novel derivatives of [1,3]selenazolo[5,4-e][1,2,4]triazolo[1,5-c]pyrimidine as a new class of selenium-containing heterocyclic architecture.

Authors:  Seddigheh Sheikhi-Mohammareh; Ali Shiri; Joel Mague
Journal:  Mol Divers       Date:  2021-03-15       Impact factor: 2.943

2.  Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties.

Authors:  Andrea Angeli; Mariana Pinteala; Stelian S Maier; Sonia Del Prete; Clemente Capasso; Bogdan C Simionescu; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

3.  Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies.

Authors:  Hana Elshaflu; Tamara R Todorović; Milan Nikolić; Aleksandar Lolić; Aleksandar Višnjevac; Stefanie Hagenow; José M Padrón; Alfonso T García-Sosa; Ivana S Djordjević; Sonja Grubišić; Holger Stark; Nenad R Filipović
Journal:  Front Chem       Date:  2018-07-03       Impact factor: 5.221
  3 in total

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