Literature DB >> 24234689

Inhibition of ethoxyresorufin-O-deethylase (EROD) activity in mixtures of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyls : EROD acitivity as biomarker in TCDD and PCB risk assessment.

M Tysklind1, A B Bosveld, P Andersson, E Verhallen, T Sinnige, W Seinen, C Rappe, M van den Berg.   

Abstract

Induction of ethoxyresorufin-O-deethylase (EROD) activity and porphyrin accumulation shows different structure-activity relationships for different polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Interactions between the two responses can strongly influence the induction and activity of EROD. The results support the conclusion that there are nonadditive interactions between nondioxin-like PCBs and dioxin-like compounds. The interaction between EROD activity and the porphyrin biosynthesis makes the prerequisite of additivity in the toxic equivalency factor concept for environmental mixtures highly spurious. Inhibition of EROD activity caused by non-dioxin like compounds could have a significant impact on the value of EROD activity as a biomarker in the present methods of risk assessment for these compounds.

Entities:  

Year:  1995        PMID： 24234689     DOI： 10.1007/BF02986768

Source DB:  PubMed          Journal:  Environ Sci Pollut Res Int        ISSN： 0944-1344            Impact factor:   4.223


  15 in total

1.  A fluorescence-based protein assay for use with a microplate reader.

Authors:  A Lorenzen; S W Kennedy
Journal:  Anal Biochem       Date:  1993-10       Impact factor: 3.365

2.  Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2.

Authors:  R W Lambrecht; P R Sinclair; N Gorman; J F Sinclair
Journal:  Arch Biochem Biophys       Date:  1992-05-01       Impact factor: 4.013

Review 3.  Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).

Authors:  S Safe
Journal:  Crit Rev Toxicol       Date:  1990       Impact factor: 5.635

4.  Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture.

Authors:  L E Rodman; S I Shedlofsky; A T Swim; L W Robertson
Journal:  Arch Biochem Biophys       Date:  1989-11-15       Impact factor: 4.013

Review 5.  Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.

Authors:  S H Safe
Journal:  Crit Rev Toxicol       Date:  1994       Impact factor: 5.635

6.  Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448.

Authors:  P R Sinclair; W J Bement; H L Bonkovsky; J F Sinclair
Journal:  Biochem J       Date:  1984-09-15       Impact factor: 3.857

7.  Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver.

Authors:  A B Rifkind; A Kanetoshi; J Orlinick; J H Capdevila; C Lee
Journal:  J Biol Chem       Date:  1994-02-04       Impact factor: 5.157

8.  H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes.

Authors:  D E Tillitt; G T Ankley; D A Verbrugge; J P Giesy; J P Ludwig; T J Kubiak
Journal:  Arch Environ Contam Toxicol       Date:  1991-07       Impact factor: 2.804

9.  Toxic potency of 3,3',4,4',5-pentachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat.

Authors:  A P Van Birgelen; J Van der Kolk; K M Fase; I Bol; H Poiger; A Brouwer; M Van den Berg
Journal:  Toxicol Appl Pharmacol       Date:  1994-08       Impact factor: 4.219

10.  Toxicity of polychlorinated biphenyl with special reference to porphyrin metabolism.

Authors:  S Sano; S Kawanishi; Y Seki
Journal:  Environ Health Perspect       Date:  1985-02       Impact factor: 9.031
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  2 in total

1.  Assessment of cytotoxicity, genotoxicity and 7-ethoxyresorufin-O-deethylase (EROD) induction in sediment extracts from New Zealand urban estuaries.

Authors:  Patrick Heinrich; Lara L Petschick; Grant L Northcott; Louis A Tremblay; James M Ataria; Thomas Braunbeck
Journal:  Ecotoxicology       Date:  2017-01-12       Impact factor: 2.823

2.  Comparative study of dioxin contamination from forest soil samples (BZE II) by mass spectrometry and EROD bioassay.

Authors:  Florian Mertes; John Mumbo; Marchela Pandelova; Silke Bernhöft; Claudia Corsten; Bernhard Henkelmann; Bernd M Bussian; Karl-Werner Schramm
Journal:  Environ Sci Pollut Res Int       Date:  2016-09-10       Impact factor: 4.223
  2 in total

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