Literature DB >> 242323

The mechanism of C-4 demethylation during cholesterol biosynthesis.

D C Wilton, M Akhtar.   

Abstract

The conversion of 4,4-dimethylcholest-7-enol into 4alpha-methylcholest-7-enol by rat liver microsomal preparations involves the decarboxylation of a sterol 3-oxo-4alpha-carboxylic acid. By using an (18)O-labelled substrate it was shown that this decarboxylation does not involve a Schiff-base intermediate.

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Year:  1975        PMID： 242323      PMCID： PMC1165609          DOI： 10.1042/bj1490233

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

1.  Ketonic intermediates in the demethylation of lanosterol.

Authors:  M LINDBERG; F GAUTSCHI; K BLOCH
Journal:  J Biol Chem       Date:  1963-05       Impact factor: 5.157

2.  18O studies of the mechanisms of yeast and muscle aldolases.

Authors:  E J Heron; R M Caprioli
Journal:  Biochemistry       Date:  1974-10-08       Impact factor: 3.162

3.  Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.

Authors:  A D Rahimtula; J L Gaylor
Journal:  J Biol Chem       Date:  1972-01-10       Impact factor: 5.157

4.  Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.

Authors:  A C Swindell; J L Gaylor
Journal:  J Biol Chem       Date:  1968-11-10       Impact factor: 5.157

5.  The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

Authors:  D C Wilton; K A Munday; S J Skinner; M Akhtar
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

6.  Oxaloacetate decarboxylase from cod. Mechanism of action and stereoselective reduction of pyruvate by borohydride.

Authors:  G W Kosicki; F H Westheimer
Journal:  Biochemistry       Date:  1968-12       Impact factor: 3.162

7.  The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.

Authors:  I A Watkinson; D C Wilton; K A Munday; M Akhtar
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857

8.  Oxaloacetate decarboxylases of rat liver.

Authors:  B Dean; W Bartley
Journal:  Biochem J       Date:  1973-12       Impact factor: 3.857
  8 in total
  1 in total

1.  The chemical mechanism of sheep liver 6-phosphogluconate dehydrogenase. A Schiff-base intermediate is not involved.

Authors:  C M Topham; K Dalziel
Journal:  Biochem J       Date:  1986-03-15       Impact factor: 3.857
  1 in total

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