Literature DB >> 24225941

Preserving youth: does rapamycin deliver?

Simon C Johnson1, George M Martin, Peter S Rabinovitch, Matt Kaeberlein.   

Abstract

Research suggests that the drug rapamycin slows mammalian aging, but a provocative new study has gained attention by claiming to show it does not.

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Year:  2013        PMID： 24225941      PMCID： PMC4019780          DOI： 10.1126/scitranslmed.3007316

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  10 in total

1.  Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.

Authors:  J Julie Wu; Jie Liu; Edmund B Chen; Jennifer J Wang; Liu Cao; Nisha Narayan; Marie M Fergusson; Ilsa I Rovira; Michele Allen; Danielle A Springer; Cory U Lago; Shuling Zhang; Wendy DuBois; Theresa Ward; Rafael deCabo; Oksana Gavrilova; Beverly Mock; Toren Finkel
Journal:  Cell Rep       Date:  2013-08-29       Impact factor: 9.423

2.  Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Authors:  Richard A Miller; David E Harrison; C M Astle; Joseph A Baur; Angela Rodriguez Boyd; Rafael de Cabo; Elizabeth Fernandez; Kevin Flurkey; Martin A Javors; James F Nelson; Carlos J Orihuela; Scott Pletcher; Zelton Dave Sharp; David Sinclair; Joseph W Starnes; J Erby Wilkinson; Nancy L Nadon; Randy Strong
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-10-25       Impact factor: 6.053

3.  Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

Authors:  Vladimir N Anisimov; Mark A Zabezhinski; Irina G Popovich; Tatiana S Piskunova; Anna V Semenchenko; Margarita L Tyndyk; Maria N Yurova; Svetlana V Rosenfeld; Mikhail V Blagosklonny
Journal:  Cell Cycle       Date:  2011-12-15       Impact factor: 4.534

Review 4.  mTOR is a key modulator of ageing and age-related disease.

Authors:  Simon C Johnson; Peter S Rabinovitch; Matt Kaeberlein
Journal:  Nature       Date:  2013-01-17       Impact factor: 49.962

5.  Rapamycin extends life and health in C57BL/6 mice.

Authors:  Yiqiang Zhang; Alex Bokov; John Gelfond; Vanessa Soto; Yuji Ikeno; Gene Hubbard; Vivian Diaz; Lauren Sloane; Keith Maslin; Stephen Treaster; Samantha Réndon; Holly van Remmen; Walter Ward; Martin Javors; Arlan Richardson; Steven N Austad; Kathleen Fischer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-05-16       Impact factor: 6.053

6.  Rapamycin extends murine lifespan but has limited effects on aging.

Authors:  Frauke Neff; Diana Flores-Dominguez; Devon P Ryan; Marion Horsch; Susanne Schröder; Thure Adler; Luciana Caminha Afonso; Juan Antonio Aguilar-Pimentel; Lore Becker; Lillian Garrett; Wolfgang Hans; Moritz M Hettich; Richard Holtmeier; Sabine M Hölter; Kristin Moreth; Cornelia Prehn; Oliver Puk; Ildikó Rácz; Birgit Rathkolb; Jan Rozman; Beatrix Naton; Rainer Ordemann; Jerzy Adamski; Johannes Beckers; Raffi Bekeredjian; Dirk H Busch; Gerhard Ehninger; Jochen Graw; Heinz Höfler; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Jörg Stypmann; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Helmut Fuchs; Valérie Gailus-Durner; Martin Hrabe de Angelis; Dan Ehninger
Journal:  J Clin Invest       Date:  2013-07-25       Impact factor: 14.808

7.  Late-life rapamycin treatment reverses age-related heart dysfunction.

Authors:  James M Flynn; Monique N O'Leary; Christopher A Zambataro; Emmeline C Academia; Michael P Presley; Brittany J Garrett; Artem Zykovich; Sean D Mooney; Randy Strong; Clifford J Rosen; Pankaj Kapahi; Michael D Nelson; Brian K Kennedy; Simon Melov
Journal:  Aging Cell       Date:  2013-07-07       Impact factor: 9.304

8.  Rapamycin slows aging in mice.

Authors:  John E Wilkinson; Lisa Burmeister; Susan V Brooks; Chi-Chao Chan; Sabrina Friedline; David E Harrison; James F Hejtmancik; Nancy Nadon; Randy Strong; Lauren K Wood; Maria A Woodward; Richard A Miller
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304

9.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Authors:  David E Harrison; Randy Strong; Zelton Dave Sharp; James F Nelson; Clinton M Astle; Kevin Flurkey; Nancy L Nadon; J Erby Wilkinson; Krystyna Frenkel; Christy S Carter; Marco Pahor; Martin A Javors; Elizabeth Fernandez; Richard A Miller
Journal:  Nature       Date:  2009-07-08       Impact factor: 49.962

10.  Longevity and aging.

Authors:  Matt Kaeberlein
Journal:  F1000Prime Rep       Date:  2013-03-04
  10 in total
  22 in total

Review 1.  Healthy aging: The ultimate preventative medicine.

Authors:  Matt Kaeberlein; Peter S Rabinovitch; George M Martin
Journal:  Science       Date:  2015-12-04       Impact factor: 47.728

2.  Activation of autophagy by rapamycin does not protect oligodendrocytes against protein aggregate formation and cell death induced by proteasomal inhibition.

Authors:  Monika Noack; Christiane Richter-Landsberg
Journal:  J Mol Neurosci       Date:  2014-07-29       Impact factor: 3.444

Review 3.  Rapamycin and ageing: when, for how long, and how much?

Authors:  Matt Kaeberlein
Journal:  J Genet Genomics       Date:  2014-08-07       Impact factor: 4.275

4.  A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae.

Authors:  Mitchell B Lee; Daniel T Carr; Michael G Kiflezghi; Yan Ting Zhao; Deborah B Kim; Socheata Thon; Margarete D Moore; Mary Ann K Li; Matt Kaeberlein
Journal:  Geroscience       Date:  2017-07-13       Impact factor: 7.713

5.  How healthy is the healthspan concept?

Authors:  Matt Kaeberlein
Journal:  Geroscience       Date:  2018-08-06       Impact factor: 7.713

6.  Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

Authors:  Arlan Richardson; Kathleen E Fischer; John R Speakman; Rafael de Cabo; Sarah J Mitchell; Charlotte A Peterson; Peter Rabinovitch; Ying A Chiao; George Taffet; Richard A Miller; René C Rentería; James Bower; Donald K Ingram; Warren C Ladiges; Yuji Ikeno; Felipe Sierra; Steven N Austad
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2015-08-22       Impact factor: 6.053

Review 7.  Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.

Authors:  Nicole E Cummings; Dudley W Lamming
Journal:  Mol Cell Endocrinol       Date:  2016-11-22       Impact factor: 4.102

8.  Rapamycin reduces Drosophila longevity under low nutrition.

Authors:  Eugenia Villa-Cuesta; Frances Fan; David M Rand
Journal:  IOSR J Pharm       Date:  2014-08

Review 9.  The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.

Authors:  M Kaeberlein
Journal:  Vet Pathol       Date:  2015-06-15       Impact factor: 2.221

Review 10.  Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

Authors:  Timothy Nacarelli; Ashley Azar; Christian Sell
Journal:  Exp Gerontol       Date:  2014-11-06       Impact factor: 4.032
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