Literature DB >> 25269671

Rapamycin and ageing: when, for how long, and how much?

Matt Kaeberlein1.   

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Year:  2014        PMID： 25269671      PMCID： PMC4401992          DOI： 10.1016/j.jgg.2014.06.009

Source DB:  PubMed          Journal:  J Genet Genomics        ISSN： 1673-8527            Impact factor:   4.275


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  37 in total

1.  Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.

Authors:  Matt Kaeberlein; R Wilson Powers; Kristan K Steffen; Eric A Westman; Di Hu; Nick Dang; Emily O Kerr; Kathryn T Kirkland; Stanley Fields; Brian K Kennedy
Journal:  Science       Date:  2005-11-18       Impact factor: 47.728

2.  The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.

Authors:  Kailiang Jia; Di Chen; Donald L Riddle
Journal:  Development       Date:  2004-07-14       Impact factor: 6.868

3.  mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.

Authors:  Chong Chen; Yu Liu; Yang Liu; Pan Zheng
Journal:  Sci Signal       Date:  2009-11-24       Impact factor: 8.192

4.  Rapamycin extends life and health in C57BL/6 mice.

Authors:  Yiqiang Zhang; Alex Bokov; John Gelfond; Vanessa Soto; Yuji Ikeno; Gene Hubbard; Vivian Diaz; Lauren Sloane; Keith Maslin; Stephen Treaster; Samantha Réndon; Holly van Remmen; Walter Ward; Martin Javors; Arlan Richardson; Steven N Austad; Kathleen Fischer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-05-16       Impact factor: 6.053

5.  Rapamycin extends murine lifespan but has limited effects on aging.

Authors:  Frauke Neff; Diana Flores-Dominguez; Devon P Ryan; Marion Horsch; Susanne Schröder; Thure Adler; Luciana Caminha Afonso; Juan Antonio Aguilar-Pimentel; Lore Becker; Lillian Garrett; Wolfgang Hans; Moritz M Hettich; Richard Holtmeier; Sabine M Hölter; Kristin Moreth; Cornelia Prehn; Oliver Puk; Ildikó Rácz; Birgit Rathkolb; Jan Rozman; Beatrix Naton; Rainer Ordemann; Jerzy Adamski; Johannes Beckers; Raffi Bekeredjian; Dirk H Busch; Gerhard Ehninger; Jochen Graw; Heinz Höfler; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Jörg Stypmann; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Helmut Fuchs; Valérie Gailus-Durner; Martin Hrabe de Angelis; Dan Ehninger
Journal:  J Clin Invest       Date:  2013-07-25       Impact factor: 14.808

6.  Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

Authors:  Pankaj Kapahi; Brian M Zid; Tony Harper; Daniel Koslover; Viveca Sapin; Seymour Benzer
Journal:  Curr Biol       Date:  2004-05-25       Impact factor: 10.834

7.  4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

Authors:  Brian M Zid; Aric N Rogers; Subhash D Katewa; Misha A Vargas; Marysia C Kolipinski; Tony Au Lu; Seymour Benzer; Pankaj Kapahi
Journal:  Cell       Date:  2009-10-02       Impact factor: 41.582

8.  Rapamycin slows aging in mice.

Authors:  John E Wilkinson; Lisa Burmeister; Susan V Brooks; Chi-Chao Chan; Sabrina Friedline; David E Harrison; James F Hejtmancik; Nancy Nadon; Randy Strong; Lauren K Wood; Maria A Woodward; Richard A Miller
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304

Review 9.  mTOR Inhibition: From Aging to Autism and Beyond.

Authors:  Matt Kaeberlein
Journal:  Scientifica (Cairo)       Date:  2013-11-26

10.  Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.

Authors:  Richard A Miller; David E Harrison; Clinton M Astle; Elizabeth Fernandez; Kevin Flurkey; Melissa Han; Martin A Javors; Xinna Li; Nancy L Nadon; James F Nelson; Scott Pletcher; Adam B Salmon; Zelton Dave Sharp; Sabrina Van Roekel; Lynn Winkleman; Randy Strong
Journal:  Aging Cell       Date:  2014-02-09       Impact factor: 9.304
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  19 in total

1.  mTOR inhibitors for treatment of low-risk prostate cancer.

Authors:  Michael A Liss; Lanette Rickborn; John DiGiovanni; Dean Bacich; Linda A DeGraffenried; Manish Parihar; Ian M Thompson; Zelton Dave Sharp
Journal:  Med Hypotheses       Date:  2018-06-05       Impact factor: 1.538

Review 2.  The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.

Authors:  M Kaeberlein
Journal:  Vet Pathol       Date:  2015-06-15       Impact factor: 2.221

3.  A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

Authors:  Silvan R Urfer; Tammi L Kaeberlein; Susan Mailheau; Philip J Bergman; Kate E Creevy; Daniel E L Promislow; Matt Kaeberlein
Journal:  Geroscience       Date:  2017-04-03       Impact factor: 7.713

4.  Metformin Treatment in Old Rats and Effects on Mitochondrial Integrity.

Authors:  Allen Herbst; Austin Hoang; Chiye Kim; Judd M Aiken; Debbie McKenzie; Deena S Goldwater; Jonathan Wanagat
Journal:  Rejuvenation Res       Date:  2021-12       Impact factor: 4.663

5.  Sirolimus treatment induces dose-dependent involution of the thymus with elevated cellular respiration in BALB/c mice.

Authors:  Saeeda Almarzooqi; Charu Sharma; Dhanya Saraswathiamma; Ahmed R Alsuwaidi; Noura Hadid; Abdul-Kader Souid; Alia Albawardi
Journal:  Am J Transl Res       Date:  2022-07-15       Impact factor: 3.940

6.  The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.

Authors:  P M Treuting; J M Snyder; Y Ikeno; P N Schofield; J M Ward; J P Sundberg
Journal:  Vet Pathol       Date:  2016-01-20       Impact factor: 2.221

Review 7.  The dog aging project: translational geroscience in companion animals.

Authors:  Matt Kaeberlein; Kate E Creevy; Daniel E L Promislow
Journal:  Mamm Genome       Date:  2016-05-03       Impact factor: 2.957

8.  Gerosuppression by pan-mTOR inhibitors.

Authors:  Olga V Leontieva; Mikhail V Blagosklonny
Journal:  Aging (Albany NY)       Date:  2016-12-30       Impact factor: 5.682

9.  Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction.

Authors:  Michael Garratt; Shinichi Nakagawa; Mirre J P Simons
Journal:  Aging Cell       Date:  2016-05-03       Impact factor: 9.304

Review 10.  Building for the future: essential infrastructure for rodent ageing studies.

Authors:  Sara E Wells; Ilaria Bellantuono
Journal:  Mamm Genome       Date:  2016-05-24       Impact factor: 2.957
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