Literature DB >> 24222566

Enhancement of mass spectrometric detection of LTC4, LTD 4, and LTE 4 by derivatization.

O A Mamer1, G Just, C S Li, P Préville, S Watson, R Young, J A Yergey.   

Abstract

Several acylating reagents are synthesized and used to introduce quatemary phosphonium or ammonium or ternary sulfonium functions into a simple model of a peptido leukotriene (PLT). One of these reagents was selected for further study with LTE4, LTD4, and LTC4. We demonstrate that acylation of the free amine function of PLTs to produce the 5-triphenylphosphoniumvaleryl-amide (TPPV) derivatives enhances chemical stabilities and significantly increases responses in fast-atom bombardment and continuous-flow liquid secondary ion mass spectrometry (CF-LSIMS) relative to the native PLTs. With high-performance liquid chromatography inlet to CF-LSIMS, we demonstrate the facile detection in selected ion monitoring of the TPPV derivative of 3 pg of LTD4.

Entities:  

Year:  1994        PMID： 24222566     DOI： 10.1016/1044-0305(94)85019-4

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  10 in total

1.  Application of fast atom bombardment with tandem mass spectrometry and liquid chromatography/mass spectrometry to the analysis of acylcarnitines in human urine, blood, and tissue.

Authors:  D S Millington; D L Norwood; N Kodo; C R Roe; F Inoue
Journal:  Anal Biochem       Date:  1989-08-01       Impact factor: 3.365

2.  Derivatization of peptides to enhance ionization efficiency and control fragmentation during analysis by fast atom bombardment tandem mass spectrometry.

Authors:  D S Wagner; A Salari; D A Gage; J Leykam; J Fetter; R Hollingsworth; J T Watson
Journal:  Biol Mass Spectrom       Date:  1991-07

3.  Determination of sulfidopeptide leukotrienes in biological fluids by gas chromatography/mass spectrometry.

Authors:  M Balazy; R C Murphy
Journal:  Anal Chem       Date:  1986-05       Impact factor: 6.986

4.  Continuous-flow sample probe for fast atom bombardment mass spectrometry.

Authors:  R M Caprioli; T Fan; J S Cottrell
Journal:  Anal Chem       Date:  1986-12       Impact factor: 6.986

5.  Preparation and tandem mass spectrometric analyses of deuterium-labeled cysteine-containing leukotrienes.

Authors:  M J Raftery; G C Thorne; R S Orkiszewski; S J Gaskell
Journal:  Biomed Environ Mass Spectrom       Date:  1990-08

6.  Measurement of urinary leukotrienes by reversed-phase liquid chromatography and radioimmunoassay.

Authors:  P Tagari; D Ethier; M Carry; V Korley; S Charleson; Y Girard; R Zamboni
Journal:  Clin Chem       Date:  1989-03       Impact factor: 8.327

7.  Charge-remote fragmentation during FAB-CAD-B/E linked-scan mass spectrometry of aminoethyl-triphenylphosphonium derivatives of fatty acids.

Authors:  Y S Chang; J T Watson
Journal:  J Am Soc Mass Spectrom       Date:  1992-10       Impact factor: 3.109

8.  Slow reacting substances (SRSs): the structure identification of SRSs from rat basophil leukaemia (RBL-1) cells.

Authors:  H R Morris; G W Taylor; P J Piper; M N Samhoun; J R Tippins
Journal:  Prostaglandins       Date:  1980-02

9.  Negative ion tandem mass spectrometry of leukotriene E4, and LTE 4, metabolites: Identification of LTE 4, in human urine.

Authors:  A Sala; K Kayganich; J A Zirrolli; R C Murphy
Journal:  J Am Soc Mass Spectrom       Date:  1991-08       Impact factor: 3.109

10.  Measurement of urinary free and acylcarnitines: quantitative acylcarnitine profiling in normal humans and in several patients with metabolic errors.

Authors:  J A Montgomery; O A Mamer
Journal:  Anal Biochem       Date:  1989-01       Impact factor: 3.365
  10 in total

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