Literature DB >> 6104346

Slow reacting substances (SRSs): the structure identification of SRSs from rat basophil leukaemia (RBL-1) cells.

H R Morris, G W Taylor, P J Piper, M N Samhoun, J R Tippins.   

Abstract

Slow Reacting Substances have been produced from RBL-l cells by calcium ionophore A23187 and purified to homogeneity by high pressure liquid chromatography (HPLC). The structure of the major biologically active species has been determined by mass spectrometric examination of the intact molecule as a derivative, together with amino-acid analysis and sequence determination. The characteristic triene chromophore which we originally identified in immunologically generated SRS-A is present in RBL-l SRS, and we determine the structure of this SRS as the thio-substituted dipeptide, 5-hydroxy-6-cysteinylglycinyl-7,9,11,14-eicosatetraenoic acid.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6104346     DOI： 10.1016/0090-6980(80)90019-2

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  23 in total

Review 1.  The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.

Authors:  K Frank Austen; Akiko Maekawa; Yoshihide Kanaoka; Joshua A Boyce
Journal:  J Allergy Clin Immunol       Date:  2009-08-03       Impact factor: 10.793

Review 2.  Leukotrienes: a new approach to the biochemistry of hypersensitivity.

Authors:  P Sirois; P Borgeat
Journal:  Surv Immunol Res       Date:  1982

Review 3.  Eighth Gaddum Memorial Lecture. University of London Institute of Education, December 1980. Biological importance of prostacyclin.

Authors:  S Moncada
Journal:  Br J Pharmacol       Date:  1982-05       Impact factor: 8.739

4.  Slow reacting substances (leukotrienes): enzymes involved in their biosynthesis.

Authors:  H R Morris; G W Taylor; C M Jones; P J Piper; M N Samhoun; J R Tippins
Journal:  Proc Natl Acad Sci U S A       Date:  1982-08       Impact factor: 11.205

5.  Formation of 11-trans slow reacting substances.

Authors:  V Atrache; D E Sok; J K Pai; C J Sih
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

6.  Slow-reacting substances and their formation by a lipoxygenase pathway.

Authors:  P J Piper; M N Samhoun; J R Tippins; H R Morris; G W Taylor
Journal:  Agents Actions       Date:  1980-12

7.  Release of a slow-reacting substance from rabbit platelets.

Authors:  J M Mencia-Huerta; L Hadji; J Benveniste
Journal:  J Clin Invest       Date:  1981-12       Impact factor: 14.808

8.  An in vivo model for measuring antigen-induced SRS-A-mediated bronchoconstriction and plasma SRS-A levels in the guinea-pig.

Authors:  W H Anderson; M O'Donnell; B A Simko; A F Welton
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

9.  Generation of leukotriene B4, its all trans isomers and 5-hydroxyeicosatetraenoic acid by rat basophilic leukaemia cells.

Authors:  A W Ford-Hutchinson; P J Piper; M N Samhoun
Journal:  Br J Pharmacol       Date:  1982-05       Impact factor: 8.739

10.  Stimulation of release of prostaglandins and thromboxanes from isolated guinea pig lung cells by bradykinin, f-Met-Leu-Phe, phorbol myristate, ionophore A23187, and leukotrienes.

Authors:  C Robidoux; J P Pelé; J Maclouf; P Pradelles; P Sirois
Journal:  Inflammation       Date:  1988-08       Impact factor: 4.092
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