OBJECTIVE: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. STUDY DESIGN: A cohort of 16,045 twin pregnancies - 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. RESULTS: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. CONCLUSION: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin.
OBJECTIVE: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. STUDY DESIGN: A cohort of 16,045 twin pregnancies - 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. RESULTS: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. CONCLUSION: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin.
Authors: Linda Juel Ahrenfeldt; Lisbeth Aagaard Larsen; Rune Lindahl-Jacobsen; Axel Skytthe; Jacob V B Hjelmborg; Sören Möller; Kaare Christensen Journal: Ann Epidemiol Date: 2016-12-09 Impact factor: 3.797
Authors: Zubair H Aghai; Shivaprasad S Goudar; Archana Patel; Sarah Saleem; Sangappa M Dhaded; Avinash Kavi; Parth Lalakia; Farnaz Naqvi; Patricia L Hibberd; Elizabeth M McClure; Tracy L Nolen; Pooja Iyer; Robert L Goldenberg; Richard J Derman Journal: Reprod Health Date: 2020-12-17 Impact factor: 3.223
Authors: Reiko Miyahara; Momodou Jasseh; Grant Austin Mackenzie; Christian Bottomley; M Jahangir Hossain; Brian M Greenwood; Umberto D'Alessandro; Anna Roca Journal: BMC Pediatr Date: 2016-03-15 Impact factor: 2.125
Authors: Kristina Mattsson; Karin Källén; Anna Rignell-Hydbom; Stefan R Hansson; Thomas F McElrath; David E Cantonwine; Lars Rylander Journal: PLoS One Date: 2015-12-02 Impact factor: 3.240