BACKGROUND: Antitumor immune response is suggested to be a factor affecting the number of nodes retrieved after colorectal cancer surgery. The purpose of this study was to evaluate the correlation of antitumor immune response with the number of retrieved nodes. PATIENTS AND METHODS: Patients with colorectal cancer (n=63, TNM stage II and III) were enrolled. Inflammatory cell infiltration (ICI) was assessed on hematoxylin and eosin staining and T-cell markers (CD3, CD8, CD45RO) were evaluated using immunohistochemical methods. RESULTS: On univariate analysis, high ICI, CD3 and CD8 expression were associated with a greater number of nodes being retrieved. On multivariate analysis, tumors of the right colon (p=0.01) and high ICI (p=0.04) were independent predictors of a greater retrieval of nodes. TNM stage III tumor with low ICI was associated with reduced cancer-specific survival (p=0.02). CONCLUSION: ICI influences the number of nodes retrieved and affects survival of patients with stage III disease. Antitumor immune response may be an underlying factor determining the number of nodes retrieved after surgery for colorectal cancer.
BACKGROUND: Antitumor immune response is suggested to be a factor affecting the number of nodes retrieved after colorectal cancer surgery. The purpose of this study was to evaluate the correlation of antitumor immune response with the number of retrieved nodes. PATIENTS AND METHODS: Patients with colorectal cancer (n=63, TNM stage II and III) were enrolled. Inflammatory cell infiltration (ICI) was assessed on hematoxylin and eosin staining and T-cell markers (CD3, CD8, CD45RO) were evaluated using immunohistochemical methods. RESULTS: On univariate analysis, high ICI, CD3 and CD8 expression were associated with a greater number of nodes being retrieved. On multivariate analysis, tumors of the right colon (p=0.01) and high ICI (p=0.04) were independent predictors of a greater retrieval of nodes. TNM stage III tumor with low ICI was associated with reduced cancer-specific survival (p=0.02). CONCLUSION: ICI influences the number of nodes retrieved and affects survival of patients with stage III disease. Antitumor immune response may be an underlying factor determining the number of nodes retrieved after surgery for colorectal cancer.
Authors: Patrick Mayr; Georg Aumann; Tina Schaller; Gerhard Schenkirsch; Matthias Anthuber; Bruno Märkl Journal: Langenbecks Arch Surg Date: 2016-02-16 Impact factor: 3.445
Authors: Johanna Waidhauser; Pia Nerlinger; Florian Sommer; Sebastian Wolf; Stefan Eser; Phillip Löhr; Andreas Rank; Bruno Märkl Journal: Diagnostics (Basel) Date: 2022-06-07
Authors: Nikhil Lal; Dedrick Kok Hong Chan; Minn E Ng; Louis Vermeulen; Simon James Alexander Buczacki Journal: Br J Cancer Date: 2022-01-18 Impact factor: 9.075
Authors: Wouter B Aan de Stegge; Barbara L van Leeuwen; Marloes A G Elferink; Geertruida H de Bock Journal: PLoS One Date: 2016-05-19 Impact factor: 3.240