Literature DB >> 24221964

Gas-phase hydrogen/deuterium exchange as a molecular probe for the interaction of methanol and protonated peptides.

E Gard1, M K Green, J Bregar, C B Lebrilla.   

Abstract

The gas-phase hydrogen/deuterium (HID) exchange kinetics of several protonated amino acids and dipeptides under a background pressure of CH3OD were determined in an external source Fourier transform mass spectrometer. H/D exchange reactions occur even when the gas-phase basicity of the compound is significantly larger (> 20 kcal/mol) than methanol. In addition; greater deuterium incorporation is observed for compounds that have multiple sites of similar basicities. A mechanism is proposed that involves a structurally specific intermediate with extensive interaction between the protonated compound and methanol.

Entities:  

Year:  1994        PMID： 24221964     DOI： 10.1016/1044-0305(94)85003-8

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  4 in total

1.  Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry.

Authors:  V Katta; B T Chait
Journal:  Rapid Commun Mass Spectrom       Date:  1991-04       Impact factor: 2.419

2.  Coexisting stable conformations of gaseous protein ions.

Authors:  D Suckau; Y Shi; S C Beu; M W Senko; J P Quinn; F M Wampler; F W McLafferty
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-01       Impact factor: 11.205

3.  Deuterium exchange studies in the identification of alkylated DNA bases found in urine, by tandem mass spectrometry.

Authors:  J R Cushnir; S Naylor; J H Lamb; P B Farmer
Journal:  Rapid Commun Mass Spectrom       Date:  1990-10       Impact factor: 2.419

4.  The use of hydrogen-deuterium exchange to facilitate peptide sequencing by electrospray tandem mass spectrometry.

Authors:  N F Sepetov; O L Issakova; M Lebl; K Swiderek; D C Stahl; T D Lee
Journal:  Rapid Commun Mass Spectrom       Date:  1993-01       Impact factor: 2.419
  4 in total
  32 in total

1.  Gas phase H/D exchange kinetics: DI versus D2O.

Authors:  T G Schaaff; J L Stephenson; S A McLuckey
Journal:  J Am Soc Mass Spectrom       Date:  2000-02       Impact factor: 3.109

2.  Temperature-dependent H/D exchange of compact and elongated cytochrome c ions in the gas phase.

Authors:  Stephen J Valentine; David E Clemmer
Journal:  J Am Soc Mass Spectrom       Date:  2002-05       Impact factor: 3.109

3.  Gas-phase H/D exchange reactions of polyamine complexes: (M + H)+, (M + alkali metal+), and (M + 2H)2+

Authors: 
Journal:  J Am Soc Mass Spectrom       Date:  2000-08       Impact factor: 3.109

4.  The role of acidic residues and of sodium ion adduction on the gas-phase H/D exchange of peptides and peptide dimers.

Authors:  John C Jurchen; Russell E Cooper; Evan R Williams
Journal:  J Am Soc Mass Spectrom       Date:  2003-12       Impact factor: 3.109

5.  Further studies on the origins of asymmetric charge partitioning in protein homodimers.

Authors:  John C Jurchen; David E Garcia; Evan R Williams
Journal:  J Am Soc Mass Spectrom       Date:  2004-10       Impact factor: 3.109

6.  Multidimensional separations of ubiquitin conformers in the gas phase: relating ion cross sections to H/D exchange measurements.

Authors:  Errol W Robinson; Evan R Williams
Journal:  J Am Soc Mass Spectrom       Date:  2005-09       Impact factor: 3.109

7.  Conformationally driven gas-phase H/D exchange of dinucleotide negative ions.

Authors:  Dorothée Balbeur; Dominique Dehareng; Edwin De Pauw
Journal:  J Am Soc Mass Spectrom       Date:  2007-07-26       Impact factor: 3.109

8.  The complexation of protonated peptides with saccharides in the gas phase decreases the rates of hydrogen/deuterium exchange reactions.

Authors:  M Kirk Green; S G Penn; C B Lebrilla
Journal:  J Am Soc Mass Spectrom       Date:  1995-12       Impact factor: 3.109

9.  The bimolecular hydrogen-deuterium exchange behavior of protonated alkyl dipeptides in the gas phase.

Authors:  E H Gur; L J de Koning; N M Nibbering
Journal:  J Am Soc Mass Spectrom       Date:  1995-06       Impact factor: 3.109

10.  Rapid Differentiation of Chondroitin Sulfate Isomers by Gas-phase Hydrogen-deuterium Exchange.

Authors:  Kimberly M Alonge; Rick Harkewicz; Miklos Guttman
Journal:  Curr Mol Med       Date:  2020       Impact factor: 2.222
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