Literature DB >> 2422147

Priming effect of interferons and interleukin 2 on endogenous production of tumor necrosis factor in mice.

M Satoh, Y Shimada, H Inagawa, H Minagawa, T Kajikawa, H Oshima, S Abe, M Yamazaki, D Mizuno.   

Abstract

The effects of interferons (IFNs) and interleukin 2 (IL 2) on endogenous production of tumor necrosis factor (TNF) were investigated in mice. Production of serum TNF was triggered by iv injection of OK-432 and tested by in vitro cytotoxicity assay. Injection of recombinant IFN-gamma with OK-432 and tested by in vitro cytotoxicity assay. Injection of recombinant IFN-gamma with OK-432 or of IFN-alpha/beta, recombinant IFN-beta, recombinant IFN-alpha A/D or recombinant IL 2 six hours before OK-432 enhanced TNF production about 10-fold, which indicated priming actions of these compounds in TNF production. These findings suggest that these compounds could also be used as priming agents for endogenous production of TNF in cancer patients.

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Year:  1986        PMID： 2422147

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  13 in total

1.  Differences between interferon-alpha and -beta treatment for patients with chronic hepatitis C virus infection.

Authors:  N Furusyo; J Hayashi; M Ohmiya; Y Sawayama; Y Kawakami; I Ariyama; N Kinukawa; S Kashiwagi
Journal:  Dig Dis Sci       Date:  1999-03       Impact factor: 3.199

Review 2.  Expression of the genes of interferons and other cytokines in normal and diseased tissues of man.

Authors:  M G Tovey
Journal:  Experientia       Date:  1989-06-15

3.  Antimetastatic effect of endogenous tumor necrosis factor induced by the treatment of recombinant interferon gamma followed by an analogue (GLA-60) to synthetic lipid A subunit.

Authors:  I Saiki; H Maeda; J Murata; N Yamamoto; M Kiso; A Hasegawa; I Azuma
Journal:  Cancer Immunol Immunother       Date:  1989       Impact factor: 6.968

4.  Immunological priming attenuates the in vivo pathophysiological response to lipopolysaccharide. Comparison of cytokine production, tissue injury, and lethality in complete Freund's adjuvant-primed mice and in unprimed mice.

Authors:  L E DeForge; E Takeuchi; D T Nguyen; D G Remick
Journal:  Am J Pathol       Date:  1994-03       Impact factor: 4.307

5.  Restoration of normal febrile response to endotoxin in pyrogen-tolerant rabbits by injection with human beta interferon.

Authors:  H Kawasaki; M Moriyama; Y Ohtani; M Naitoh; H Nariuchi; A Tanaka
Journal:  Infect Immun       Date:  1987-11       Impact factor: 3.441

6.  Induction of an endogenous tumor necrosis factor in mice by murine recombinant interferon-gamma combined with a lipid A subunit analog (GLA-60) of low toxicity.

Authors:  I Saiki; H Maeda; T Sakurai; J Murata; J Iida; M Kiso; A Hasegawa; I Azuma
Journal:  Cancer Immunol Immunother       Date:  1989       Impact factor: 6.968

7.  Augmentation of endotoxin fever by recombinant human beta interferon in rabbits.

Authors:  H Kawasaki; M Moriyama; A Tanaka
Journal:  Infect Immun       Date:  1987-05       Impact factor: 3.441

8.  Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.

Authors:  J Satoh; H Seino; T Abo; S Tanaka; S Shintani; S Ohta; K Tamura; T Sawai; T Nobunaga; T Oteki
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808

9.  Intratumoral induction of tumour necrosis factor by systemic administration of Bordetella pertussis vaccine.

Authors:  H Minagawa; H Kobayashi; H Yoshida; M Teranishi; A Morikawa; S Abe; H Oshima; D I Mizuno
Journal:  Br J Cancer       Date:  1990-09       Impact factor: 7.640

10.  Endogenous tumor necrosis factor induction with Bordetella pertussis vaccine as a triggering agent and its therapeutic effect on MM46 carcinoma-bearing mice.

Authors:  H Minagawa; Y Kakamu; H Yoshida; F Tomita; H Oshima; D Mizuno
Journal:  Jpn J Cancer Res       Date:  1988-03
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