Literature DB >> 2437032

Augmentation of endotoxin fever by recombinant human beta interferon in rabbits.

H Kawasaki, M Moriyama, A Tanaka.   

Abstract

Nonpyrogenic amounts of endotoxin (0.1 to 1 ng/kg), hardly detectable by conventional Limulus amoebocyte lysate tests, could produce a fever of around 1 degree C when injected with a nonpyrogenic dose (6 X 10(5) U/kg) of recombinant human beta interferon (IFN-beta) in rabbits. Release of endogenous IFN and tumor necrosis factor by endotoxin was also dramatically increased by recombinant human IFN-beta, and their levels in the blood were closely correlated with the increase of body temperature. These data suggest, if the synergism between IFN and endotoxin also operates in the homologous system (human IFN-human cells), that contaminating endotoxin in IFNs, even if not detectable by Limulus amoebocyte lysate test, can contribute to IFN fever to a considerable extent in humans.

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Year:  1987        PMID： 2437032      PMCID： PMC260478          DOI： 10.1128/iai.55.5.1121-1125.1987

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  41 in total

1.  Pronounced antiviral activity of human interferon on bovine and porcine cells.

Authors:  I Gresser; M T Bandu; D Brouty-boye; M Tovey
Journal:  Nature       Date:  1974-10-11       Impact factor: 49.962

2.  Interferon kinetics and adverse reactions after intravenous, intramuscular, and subcutaneous injection.

Authors:  R J Wills; S Dennis; H E Spiegel; D M Gibson; P I Nadler
Journal:  Clin Pharmacol Ther       Date:  1984-05       Impact factor: 6.875

3.  The effect of febrile temperatures on biologic actions of interferons: abrogation of suppression of delayed-type hypersensitivity and antibody production.

Authors:  Y Ron; J P Dougherty; G W Duff; R K Gershon
Journal:  J Immunol       Date:  1984-10       Impact factor: 5.422

Review 4.  Interferon-alpha: current status and future promise.

Authors:  E M Bonnem; R J Spiegel
Journal:  J Biol Response Mod       Date:  1984-12

5.  Side effects of long-term treatment with human leukocyte interferon.

Authors:  S Ingimarsson; K Cantell; H Strander
Journal:  J Infect Dis       Date:  1979-10       Impact factor: 5.226

6.  Growth-inhibitory activity of recombinant human interferon-beta against cultured human cells.

Authors:  K Gomi; M Morimoto; N Nakamizo
Journal:  Gan       Date:  1983-10

Review 7.  Interleukin-1.

Authors:  C A Dinarello
Journal:  Rev Infect Dis       Date:  1984 Jan-Feb

8.  Recombinant leukocyte A interferon: pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients.

Authors:  J U Gutterman; S Fine; J Quesada; S J Horning; J F Levine; R Alexanian; L Bernhardt; M Kramer; H Spiegel; W Colburn; P Trown; T Merigan; Z Dziewanowski
Journal:  Ann Intern Med       Date:  1982-05       Impact factor: 25.391

9.  Purification and partial amino acid sequence of rabbit tumor necrosis factor.

Authors:  K Haranaka; N Satomi; A Sakurai; H Nariuchi
Journal:  Int J Cancer       Date:  1985-09-15       Impact factor: 7.396

10.  Role of prostaglandin E in the biphasic fever response to endotoxin.

Authors:  R C Skarnes; S K Brown; S S Hull; J A McCracken
Journal:  J Exp Med       Date:  1981-10-01       Impact factor: 14.307
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  4 in total

1.  Antibacterial activity of recombinant murine beta interferon.

Authors:  T Fujiki; A Tanaka
Journal:  Infect Immun       Date:  1988-03       Impact factor: 3.441

2.  Mechanism of augmentation of endotoxin fever by beta interferon in rabbits: possible participation of tumor necrosis factor (cachectin).

Authors:  H Kawasaki; M Moriyama; H Nariuchi
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

3.  Analysis of endotoxin fever in rabbits by using a monoclonal antibody to tumor necrosis factor (cachectin).

Authors:  H Kawasaki; M Moriyama; Y Ohtani; M Naitoh; A Tanaka; H Nariuchi
Journal:  Infect Immun       Date:  1989-10       Impact factor: 3.441

4.  Restoration of normal febrile response to endotoxin in pyrogen-tolerant rabbits by injection with human beta interferon.

Authors:  H Kawasaki; M Moriyama; Y Ohtani; M Naitoh; H Nariuchi; A Tanaka
Journal:  Infect Immun       Date:  1987-11       Impact factor: 3.441
  4 in total

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