Literature DB >> 2422115

Interrelationships of the "Ly-6 complex" antigens.

B A Houlden, P M Hogarth, I F McKenzie.   

Abstract

Competitive binding studies and immunoprecipitation experiments define at least five distinct epitopes encoded by Ly-6-linked genes--Ly-6A.2, Ly-6B.2, Ly-6C.2, Ly-6D.2, and ThB. Ly-6A.2, a 33 kd protein, and Ly-6D.2 are closely overlapping epitopes that can be distinguished by their unique thymus reactions of 10-20% or greater than 90%, respectively. Similarly, the Ly-6C.2 antigen present on a 14 kd moiety loosely overlaps the Ly-6B.2 antigen. Ly-6C.2 and Ly-6B.2 antigens are distinct from Ly-6A.2 and Ly-6D.2, however. ThB is a 16-18 kd antigen which is not associated on the cell surface with any other "Ly-6" antigens. In addition, independently derived antibodies made to the Ly-6C.2 antigen detect an identical epitope, as do antibodies to Ly-6A.2 and Ly-6B.2. These results imply the existence of a single antigenic site on each of these molecules.

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Year:  1986        PMID： 2422115     DOI： 10.1007/bf00373017

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  13 in total

1.  A cell surface antigenic determinant present on mouse plasmacytes and only about half of mouse thymocytes.

Authors:  M Yutoku; A L Grossberg; D Pressman
Journal:  J Immunol       Date:  1974-05       Impact factor: 5.422

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Biochemical characterization of H9/25, an allospecificity encoded by the Ly-6 region.

Authors:  F Takei
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

4.  Definition of new alloantigens encoded by genes in the Ly-6 complex.

Authors:  P M Hogarth; B A Houlden; S E Latham; V R Sutton; I F McKenzie
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

5.  Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression.

Authors:  L A Eckhardt; L A Herzenberg
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

6.  Identification of two forms of the Ly-6.2 antigen showing differential expression.

Authors:  V R Sutton; C A Mickelson; G H Tobias; P M Hogarth; I F McKenzie
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

7.  Molecular weight determination of two genetically linked cell surface murine antigens: ThB and Ly-6.

Authors:  A Matossian-Rogers; P Rogers; J A Ledbetter; L A Herzenberg
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

8.  H 9/25 monoclonal antibody recognizes a new allospecificity of mouse lymphocyte subpopulations: strain and tissue distribution.

Authors:  F Takei; G Galfrè; T Alderson; E S Lennox; C Milstein
Journal:  Eur J Immunol       Date:  1980-04       Impact factor: 5.532

9.  The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule.

Authors:  P M Hogarth; I D Walker; I F McKenzie; T A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

10.  Monoclonal antibody to murine neutrophils: identification of the Gm-2.2 specificity.

Authors:  M L Hibbs; P M Hogarth; B M Scott; R A Harris; I F McKenzie
Journal:  J Immunol       Date:  1984-11       Impact factor: 5.422
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  10 in total

1.  The isolation and sequence of the chromosomal gene and regulatory regions of Ly-6A.2.

Authors:  W L Stanford; E Bruyns; H R Snodgrass
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

2.  A monoclonal antibody to Ly-6 gene product inhibits generation of functionally active T cells and recognizes single antigenic specificity whose expression is up-regulated in virus-transformed rat fibroblast.

Authors:  A Haque; M Chamekh; J Cornelis; A Capron; S Haque
Journal:  Immunology       Date:  1990-04       Impact factor: 7.397

3.  cDNA characterization of an Ly-6.2 gene expressed in BW5147 tumor cells.

Authors:  R G Palfree; K P LeClair; A Bothwell; U Hämmerling
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

4.  The 33,000 protein precipitated by Ly-6A.2-specific antibodies is not associated with the Ly-6 polymorphism.

Authors:  B A Houlden; I F McKenzie; P M Hogarth
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

5.  New Ly-6 congenic strains.

Authors:  D Ivanyi; P Demant
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

6.  Gene for human CD59 (likely Ly-6 homologue) is located on the short arm of chromosome 11.

Authors:  U H Forsberg; V Bazil; I Stefanová; J Schröder
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

7.  Murine Ly-6 multigene family is located on chromosome 15.

Authors:  K P LeClair; M Rabin; M N Nesbitt; D Pravtcheva; F H Ruddle; R G Palfree; A Bothwell
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

8.  Expression of Ly-6A/E alloantigens in thymocyte and T-lymphocyte subsets: variability related to the Ly-6a and Ly-6b haplotypes.

Authors:  E K Codias; C Cray; R D Baler; R B Levy; T R Malek
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

9.  Isolation of a murine Ly-6 cDNA reveals a new multigene family.

Authors:  K P LeClair; R G Palfree; P M Flood; U Hammerling; A Bothwell
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598

10.  Inhibition of Ly-6A antigen expression prevents T cell activation.

Authors:  P M Flood; J P Dougherty; Y Ron
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307
  10 in total

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