G Silbernagel1, J Machann2, H-U Häring3, A Fritsche3, A Peter3. 1. 1] Department of Angiology, Swiss Cardiovascular Center, Inselspital, University of Bern, Bern, Switzerland [2] Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls University, Tübingen, Germany [3] Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the Eberhard-Karls University, Member of the German Center for Diabetes Research (DZD), Tübingen, Germany. 2. Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard-Karls University, Tübingen, Germany. 3. 1] Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls University, Tübingen, Germany [2] Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the Eberhard-Karls University, Member of the German Center for Diabetes Research (DZD), Tübingen, Germany.
Abstract
BACKGROUND/ OBJECTIVES: High intake of added sweeteners is considered to have a causal role in the pathogenesis of cardiometabolic disorders. Especially, high-fructose intake is regarded as potentially harmful to cardiometabolic health. It may cause not only weight gain but also low-grade inflammation, which represents an independent risk factor for developing type 2 diabetes and cardiovascular disease. In particular, fructose has been suggested to induce plasminogen activator inhibitor-1 (PAI-1) expression in the liver and to increase circulating inflammatory cytokines. We therefore aimed to investigate, whether high-fructose diet has an impact on PAI-1, monocyte chemoattractant protein-1 (MCP-1), e-selectin and C-reactive protein (CRP) concentrations in healthy humans. SUBJECTS/ METHODS: We studied 20 participants (12 males and 8 females) of the TUebingen FRuctose Or Glucose study. This is an exploratory, parallel, prospective, randomized, single-blinded, outpatient, hypercaloric, intervention study. The participants had a mean age of 30.9 ± 2.1 years and a mean body mass index of 26.0 ± 0.5 kg/m(2) and they received 150 g of either fructose or glucose per day for 4 weeks. RESULTS: There were neither significant changes of PAI-1, MCP-1, e-selectin and CRP after fructose (n=10) and glucose (n=10) intervention nor treatment effects (all P>0.2). Moreover, we did not observe longitudinal associations of the inflammatory parameters with triglycerides, liver fat, visceral fat and body weight in the fructose group. CONCLUSIONS: Temporary high-fructose intake does not seem to cause inflammation in apparently healthy people in this secondary analysis of a small feeding trial.
RCT Entities:
BACKGROUND/ OBJECTIVES: High intake of added sweeteners is considered to have a causal role in the pathogenesis of cardiometabolic disorders. Especially, high-fructose intake is regarded as potentially harmful to cardiometabolic health. It may cause not only weight gain but also low-grade inflammation, which represents an independent risk factor for developing type 2 diabetes and cardiovascular disease. In particular, fructose has been suggested to induce plasminogen activator inhibitor-1 (PAI-1) expression in the liver and to increase circulating inflammatory cytokines. We therefore aimed to investigate, whether high-fructose diet has an impact on PAI-1, monocyte chemoattractant protein-1 (MCP-1), e-selectin and C-reactive protein (CRP) concentrations in healthy humans. SUBJECTS/ METHODS: We studied 20 participants (12 males and 8 females) of the TUebingen FRuctose Or Glucose study. This is an exploratory, parallel, prospective, randomized, single-blinded, outpatient, hypercaloric, intervention study. The participants had a mean age of 30.9 ± 2.1 years and a mean body mass index of 26.0 ± 0.5 kg/m(2) and they received 150 g of either fructose or glucose per day for 4 weeks. RESULTS: There were neither significant changes of PAI-1, MCP-1, e-selectin and CRP after fructose (n=10) and glucose (n=10) intervention nor treatment effects (all P>0.2). Moreover, we did not observe longitudinal associations of the inflammatory parameters with triglycerides, liver fat, visceral fat and body weight in the fructose group. CONCLUSIONS: Temporary high-fructose intake does not seem to cause inflammation in apparently healthy people in this secondary analysis of a small feeding trial.
Authors: Giridhar Kanuri; Astrid Spruss; Sabine Wagnerberger; Stephan C Bischoff; Ina Bergheim Journal: Lab Invest Date: 2011-03-21 Impact factor: 5.662
Authors: Isabelle Aeberli; Philipp A Gerber; Michel Hochuli; Sibylle Kohler; Sarah R Haile; Ioanna Gouni-Berthold; Heiner K Berthold; Giatgen A Spinas; Kaspar Berneis Journal: Am J Clin Nutr Date: 2011-06-15 Impact factor: 7.045
Authors: Jessica N Kuzma; Gail Cromer; Derek K Hagman; Kara L Breymeyer; Christian L Roth; Karen E Foster-Schubert; Sarah E Holte; David S Weigle; Mario Kratz Journal: Am J Clin Nutr Date: 2016-06-29 Impact factor: 7.045
Authors: Maren R Laughlin; John P Bantle; Peter J Havel; Elizabeth Parks; David M Klurfeld; Karen Teff; Padma Maruvada Journal: Adv Nutr Date: 2014-05-14 Impact factor: 8.701
Authors: Nicola M McKeown; Hassan S Dashti; Jiantao Ma; Danielle E Haslam; Jessica C Kiefte-de Jong; Caren E Smith; Toshiko Tanaka; Mariaelisa Graff; Rozenn N Lemaitre; Denis Rybin; Emily Sonestedt; Alexis C Frazier-Wood; Dennis O Mook-Kanamori; Yanping Li; Carol A Wang; Elisabeth T M Leermakers; Vera Mikkilä; Kristin L Young; Kenneth J Mukamal; L Adrienne Cupples; Christina-Alexandra Schulz; Tzu-An Chen; Ruifang Li-Gao; Tao Huang; Wendy H Oddy; Olli Raitakari; Kenneth Rice; James B Meigs; Ulrika Ericson; Lyn M Steffen; Frits R Rosendaal; Albert Hofman; Mika Kähönen; Bruce M Psaty; Louise Brunkwall; Andre G Uitterlinden; Jorma Viikari; David S Siscovick; Ilkka Seppälä; Kari E North; Dariush Mozaffarian; Josée Dupuis; Marju Orho-Melander; Stephen S Rich; Renée de Mutsert; Lu Qi; Craig E Pennell; Oscar H Franco; Terho Lehtimäki; Mark A Herman Journal: Diabetologia Date: 2017-11-02 Impact factor: 10.460
Authors: Miguel Baena; Gemma Sangüesa; Alberto Dávalos; María-Jesús Latasa; Aleix Sala-Vila; Rosa María Sánchez; Núria Roglans; Juan Carlos Laguna; Marta Alegret Journal: Sci Rep Date: 2016-05-19 Impact factor: 4.379