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Literature DB >> 24217316

A new world of Polycombs: unexpected partnerships and emerging functions.

Abstract

Polycomb group (PcG) proteins are epigenetic repressors that are essential for the transcriptional control of cell differentiation and development. PcG-mediated repression is associated with specific post-translational histone modifications and is thought to involve both biochemical and physical modulation of chromatin structure. Recent advances show that PcG complexes comprise a multiplicity of variants and are far more biochemically diverse than previously thought. The importance of these new PcG complexes for normal development and disease, their targeting mechanisms and their shifting roles in the course of differentiation are now the subject of investigation and the focus of this Review.

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Year: 2013 PMID： 24217316 DOI： 10.1038/nrg3603

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

143 in total

1. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

Authors: Antoine H F M Peters; Stefan Kubicek; Karl Mechtler; Roderick J O'Sullivan; Alwin A H A Derijck; Laura Perez-Burgos; Alexander Kohlmaier; Susanne Opravil; Makoto Tachibana; Yoichi Shinkai; Joost H A Martens; Thomas Jenuwein
Journal: Mol Cell Date: 2003-12 Impact factor: 17.970

2. Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes.

Authors: Carrie S Ketel; Erica F Andersen; Marcus L Vargas; Jinkyo Suh; Susan Strome; Jeffrey A Simon
Journal: Mol Cell Biol Date: 2005-08 Impact factor: 4.272

3. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation.

Authors: Wen Yuan; Mo Xu; Chang Huang; Nan Liu; She Chen; Bing Zhu
Journal: J Biol Chem Date: 2011-01-14 Impact factor: 5.157

4. Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.

Authors: Jan Willem Voncken; Bernard A J Roelen; Mieke Roefs; Stijn de Vries; Els Verhoeven; Silvia Marino; Jacqueline Deschamps; Maarten van Lohuizen
Journal: Proc Natl Acad Sci U S A Date: 2003-02-14 Impact factor: 11.205

5. SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex.

Authors: Takehito Furuyama; Rakhee Banerjee; Thomas R Breen; Peter J Harte
Journal: Curr Biol Date: 2004-10-26 Impact factor: 10.834

6. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.

Authors: Tetyana Klymenko; Bernadett Papp; Wolfgang Fischle; Thomas Köcher; Malgorzata Schelder; Cornelia Fritsch; Brigitte Wild; Matthias Wilm; Jürg Müller
Journal: Genes Dev Date: 2006-04-17 Impact factor: 11.361

7. Polycomb complexes act redundantly to repress genomic repeats and genes.

Authors: Martin Leeb; Diego Pasini; Maria Novatchkova; Markus Jaritz; Kristian Helin; Anton Wutz
Journal: Genes Dev Date: 2010-02-01 Impact factor: 11.361

8. Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.

Authors: Andrei Kuzmichev; Thomas Jenuwein; Paul Tempst; Danny Reinberg
Journal: Mol Cell Date: 2004-04-23 Impact factor: 17.970

9. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

Authors: Jamy C Peng; Anton Valouev; Tomek Swigut; Junmei Zhang; Yingming Zhao; Arend Sidow; Joanna Wysocka
Journal: Cell Date: 2009-12-24 Impact factor: 41.582

10. The role of the histone H2A ubiquitinase Sce in Polycomb repression.

Authors: Luis Gutiérrez; Katarzyna Oktaba; Johanna C Scheuermann; Maria Cristina Gambetta; Nga Ly-Hartig; Jürg Müller
Journal: Development Date: 2011-11-17 Impact factor: 6.868

144 in total

Review 1. Polycomb and Trithorax Group Genes in Drosophila.

Authors: Judith A Kassis; James A Kennison; John W Tamkun
Journal: Genetics Date: 2017-08 Impact factor: 4.562

2. Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes.

Authors: Atsushi Onodera; Damon J Tumes; Yukiko Watanabe; Kiyoshi Hirahara; Atsushi Kaneda; Fumihiro Sugiyama; Yutaka Suzuki; Toshinori Nakayama
Journal: Mol Cell Biol Date: 2015-08-31 Impact factor: 4.272

3. Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.

Authors: Zachary Z Brown; Manuel M Müller; Ha Eun Kong; Peter W Lewis; Tom W Muir
Journal: Angew Chem Int Ed Engl Date: 2015-04-14 Impact factor: 15.336

A new world of Polycombs: unexpected partnerships and emerging functions.

1. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

2. Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes.

3. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation.

4. Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.

5. SIR2 is required for polycomb silencing and is associated with an E(Z) histone methyltransferase complex.

6. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.

7. Polycomb complexes act redundantly to repress genomic repeats and genes.

8. Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.

9. Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

10. The role of the histone H2A ubiquitinase Sce in Polycomb repression.

Review 1. Polycomb and Trithorax Group Genes in Drosophila.

2. Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes.

3. Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.

4. ZRF1 Chromatin Regulators Have Polycomb Silencing and Independent Roles in Development.

Review 5. Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease.

Review 6. Preserving genome integrity and function: the DNA damage response and histone modifications.

Review 7. Epigenetic regulation of T helper cells and intestinal pathogenicity.

8. Ash1 counteracts Polycomb repression independent of histone H3 lysine 36 methylation.

9. Causal Gene Regulatory Network Modeling and Genomics: Second-Generation Challenges.

Review 10. Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.