| Literature DB >> 24212671 |
Juan Song1, Jiaqi Sun, Jonathan Moss, Zhexing Wen, Gerald J Sun, Derek Hsu, Chun Zhong, Heydar Davoudi, Kimberly M Christian, Nicolas Toni, Guo-Li Ming, Hongjun Song.
Abstract
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.Entities:
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Year: 2013 PMID： 24212671 PMCID： PMC4096812 DOI： 10.1038/nn.3572
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884