Kenneth J Sufka1, Melissa J Loria2, Kevin Lewellyn3, Jordan K Zjawiony4, Zulfiqar Ali5, Naohito Abe5, Ikhlas A Khan6. 1. Department of Psychology, University of Mississippi, University, MS 38677, USA; Department of Pharmacology, University of Mississippi, University, MS 38677, USA; Research Institute of Pharmaceutical Science, University of Mississippi, University, MS 38677, USA. Electronic address: pysufka@olemiss.edu. 2. Department of Psychology, University of Mississippi, University, MS 38677, USA. 3. Department of Pharmacognosy, University of Mississippi, University, MS 38677, USA. 4. Department of Pharmacognosy, University of Mississippi, University, MS 38677, USA; Research Institute of Pharmaceutical Science, University of Mississippi, University, MS 38677, USA. 5. National Center for Natural Product Research, University of Mississippi, University, MS 38677, USA. 6. Department of Pharmacognosy, University of Mississippi, University, MS 38677, USA; Research Institute of Pharmaceutical Science, University of Mississippi, University, MS 38677, USA; National Center for Natural Product Research, University of Mississippi, University, MS 38677, USA.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Consumer use of botanicals has increased despite, in many instances, the paucity of research demonstrating efficacy or identifying liabilities. This research employed the place preference/aversion paradigm to characterize the psychoactive properties of Salvia divinorum extract (10, 30, 100mg/kg), salvinorin A (0.1, 0.3, 1.0mg/kg), Mitragyna speciosa MeOH extract (50, 100, 300 mg/kg), Mitragyna speciosa alkaloid-enriched fraction (12.5, 25, 75 mg/kg) and mitragynine (5, 10, 30 mg/kg) in rats. MATERIAL AND METHODS: Following apparatus habituation and baseline preference scores, male Sprague-Dawley rats were given eight counter-balanced drug versus vehicle conditioning trials followed by a preference test conducted under drug-free states. S(+)-amphetamine (1mg/kg) served as the positive control (in Exp. 2) and haloperidol (0.8, 1.0mg/kg) served as the negative control in both studies. RESULTS: Rats displayed place aversion to both Salvia divinorum and salvinorin A that exceeded that of haloperidol. Rats showed place preference to mitragynine that was similar to that of S(+)-amphetamine. This CPP effect was much less pronounced with the Mitragyna speciosa extract and its fraction. CONCLUSIONS: These findings suggest that both botanicals possess liabilities, albeit somewhat different, that warrant caution in their use.
ETHNOPHARMACOLOGICAL RELEVANCE: Consumer use of botanicals has increased despite, in many instances, the paucity of research demonstrating efficacy or identifying liabilities. This research employed the place preference/aversion paradigm to characterize the psychoactive properties of Salvia divinorum extract (10, 30, 100mg/kg), salvinorin A (0.1, 0.3, 1.0mg/kg), Mitragyna speciosaMeOH extract (50, 100, 300 mg/kg), Mitragyna speciosa alkaloid-enriched fraction (12.5, 25, 75 mg/kg) and mitragynine (5, 10, 30 mg/kg) in rats. MATERIAL AND METHODS: Following apparatus habituation and baseline preference scores, male Sprague-Dawley rats were given eight counter-balanced drug versus vehicle conditioning trials followed by a preference test conducted under drug-free states. S(+)-amphetamine (1mg/kg) served as the positive control (in Exp. 2) and haloperidol (0.8, 1.0mg/kg) served as the negative control in both studies. RESULTS:Rats displayed place aversion to both Salvia divinorum and salvinorin A that exceeded that of haloperidol. Rats showed place preference to mitragynine that was similar to that of S(+)-amphetamine. This CPP effect was much less pronounced with the Mitragyna speciosa extract and its fraction. CONCLUSIONS: These findings suggest that both botanicals possess liabilities, albeit somewhat different, that warrant caution in their use.
Authors: Amy W M Ewald; Peter J Bosch; Aimee Culverhouse; Rachel Saylor Crowley; Benjamin Neuenswander; Thomas E Prisinzano; Bronwyn M Kivell Journal: Psychopharmacology (Berl) Date: 2017-05-23 Impact factor: 4.530
Authors: Kate L White; J Elliott Robinson; Hu Zhu; Jeffrey F DiBerto; Prabhakar R Polepally; Jordan K Zjawiony; David E Nichols; C J Malanga; Bryan L Roth Journal: J Pharmacol Exp Ther Date: 2014-10-15 Impact factor: 4.030
Authors: Soumen Chakraborty; Rajendra Uprety; Samuel T Slocum; Takeshi Irie; Valerie Le Rouzic; Xiaohai Li; Lisa L Wilson; Brittany Scouller; Amy F Alder; Andrew C Kruegel; Michael Ansonoff; Andras Varadi; Shainnel O Eans; Amanda Hunkele; Abdullah Allaoa; Sanjay Kalra; Jin Xu; Ying Xian Pan; John Pintar; Bronwyn M Kivell; Gavril W Pasternak; Michael D Cameron; Jay P McLaughlin; Dalibor Sames; Susruta Majumdar Journal: J Med Chem Date: 2021-11-16 Impact factor: 7.446
Authors: Bronwyn M Kivell; Kelly F Paton; Nitin Kumar; Aashish S Morani; Aimee Culverhouse; Amy Shepherd; Susan A Welsh; Andrew Biggerstaff; Rachel S Crowley; Thomas E Prisinzano Journal: Molecules Date: 2018-10-11 Impact factor: 4.411