| Literature DB >> 24210736 |
Anne Irene Hagen1, Lovise Mæhle2, Nina Vedå2, Hildegunn Høberg Vetti3, Astrid Stormorken2, Trond Ludvigsen4, Bente Guntvedt5, Anne Elisabeth Isern6, Ellen Schlichting7, Geir Kleppe8, Anna Bofin9, Hans Petter Gullestad10, Pål Møller2.
Abstract
The aim of this study was to evaluate the outcome of risk-reducing mastectomy in BRCA1/2 mutation carriers with and without breast cancer. Uptake, methods of operation and reconstruction, complications, patient satisfaction and histopathological findings were registered at all five departments of genetics in Norway. Data from 267 affected and unaffected BRCA1/2 mutation carriers were analyzed, including a study-specific questionnaire returned by 178 mutation carriers. There was a steady increase in the uptake of risk-reducing mastectomies during the study period. Complications were observed in 106/266 (39.7%) women. Patient satisfaction was high. The majority of women expressed great relief after risk-reducing mastectomy and would have chosen the same option again.Entities:
Keywords: BRCA1; BRCA2; DIEP; Reconstruction; Risk-reducing mastectomy; SGAP; TRAM; deep inferior epigastric perforator flap; superior gluteal artery perforator flap; transverse rectus abdominal myocutaneous flap
Mesh：
Year: 2013 PMID： 24210736 DOI： 10.1016/j.breast.2013.10.002
Source DB: PubMed Journal: Breast ISSN： 0960-9776 Impact factor: 4.380