Changhyun Kim1, Christine J Ko2, David J Leffell3. 1. Department of Dermatology, Yale University, New Haven, Connecticut. 2. Department of Dermatology, Yale University, New Haven, Connecticut; Department of Pathology, Yale University, New Haven, Connecticut. 3. Department of Dermatology, Yale University, New Haven, Connecticut. Electronic address: david.leffell@yale.edu.
Abstract
BACKGROUND: Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE). OBJECTIVE: We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs. METHODS: We identified 22 patients with 4 or more biopsy-diagnosed LE SCCs during a 4.5-year study period. The location, size, treatment, and clinical outcome of each LE SCC were recorded. RESULTS: Of the 22 patients studied, 18 were female. Of the 360 SCCs our patients developed, 260 (72.2%) were on the LE. The incidence of SCCs in these patients was nearly 7 times greater than the incidence of basal cell carcinoma in the same patients. LIMITATIONS: The number of patients is small and limits definitive conclusions about prevalence of SCCs on the LE in the general population. CONCLUSIONS: LE SCCs are a distinct subset of cutaneous SCCs and may have distinctive clinical features and biologic behavior requiring additional study.
BACKGROUND: Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE). OBJECTIVE: We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs. METHODS: We identified 22 patients with 4 or more biopsy-diagnosed LE SCCs during a 4.5-year study period. The location, size, treatment, and clinical outcome of each LE SCC were recorded. RESULTS: Of the 22 patients studied, 18 were female. Of the 360 SCCs our patients developed, 260 (72.2%) were on the LE. The incidence of SCCs in these patients was nearly 7 times greater than the incidence of basal cell carcinoma in the same patients. LIMITATIONS: The number of patients is small and limits definitive conclusions about prevalence of SCCs on the LE in the general population. CONCLUSIONS: LE SCCs are a distinct subset of cutaneous SCCs and may have distinctive clinical features and biologic behavior requiring additional study.
Authors: Manuel António Campos; Sofia Macedo; Margarida Sá Fernandes; Ana Pestana; Joana Pardal; Rui Batista; João Vinagre; Agostinho Sanches; Armando Baptista; José Manuel Lopes; Paula Soares Journal: Genes (Basel) Date: 2020-07-06 Impact factor: 4.096