Literature DB >> 24209756

Trivalent chromatin marks the way in.

Eriona Hysolli1, In-Hyun Park.   

Abstract

Recently in Cell, Wapinski et al. (2013) investigated the epigenetic mechanisms underlying the direct conversion of fibroblasts to induced neurons (iNs). They found that Ascl1 acts as a pioneer factor at neurogenic loci marked by a closed "trivalent" chromatin state in cells permissive to direct conversion, but not in restrictive cell types.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24209756      PMCID： PMC4665996          DOI： 10.1016/j.stem.2013.10.007

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  11 in total

1.  Stepwise reprogramming of B cells into macrophages.

Authors:  Huafeng Xie; Min Ye; Ru Feng; Thomas Graf
Journal:  Cell       Date:  2004-05-28       Impact factor: 41.582

Review 2.  Induced neuronal cells: how to make and define a neuron.

Authors:  Nan Yang; Yi Han Ng; Zhiping P Pang; Thomas C Südhof; Marius Wernig
Journal:  Cell Stem Cell       Date:  2011-12-02       Impact factor: 24.633

3.  A bivalent chromatin structure marks key developmental genes in embryonic stem cells.

Authors:  Bradley E Bernstein; Tarjei S Mikkelsen; Xiaohui Xie; Michael Kamal; Dana J Huebert; James Cuff; Ben Fry; Alex Meissner; Marius Wernig; Kathrin Plath; Rudolf Jaenisch; Alexandre Wagschal; Robert Feil; Stuart L Schreiber; Eric S Lander
Journal:  Cell       Date:  2006-04-21       Impact factor: 41.582

Review 4.  Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies.

Authors:  Julia Ladewig; Philipp Koch; Oliver Brüstle
Journal:  Nat Rev Mol Cell Biol       Date:  2013-03-13       Impact factor: 94.444

5.  Expression of a single transfected cDNA converts fibroblasts to myoblasts.

Authors:  R L Davis; H Weintraub; A B Lassar
Journal:  Cell       Date:  1987-12-24       Impact factor: 41.582

6.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

7.  Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

Authors:  Orly L Wapinski; Thomas Vierbuchen; Kun Qu; Qian Yi Lee; Soham Chanda; Daniel R Fuentes; Paul G Giresi; Yi Han Ng; Samuele Marro; Norma F Neff; Daniela Drechsel; Ben Martynoga; Diogo S Castro; Ashley E Webb; Thomas C Südhof; Anne Brunet; Francois Guillemot; Howard Y Chang; Marius Wernig
Journal:  Cell       Date:  2013-10-24       Impact factor: 41.582

Review 8.  Pioneer transcription factors: establishing competence for gene expression.

Authors:  Kenneth S Zaret; Jason S Carroll
Journal:  Genes Dev       Date:  2011-11-01       Impact factor: 11.361

9.  Induction of human neuronal cells by defined transcription factors.

Authors:  Zhiping P Pang; Nan Yang; Thomas Vierbuchen; Austin Ostermeier; Daniel R Fuentes; Troy Q Yang; Ami Citri; Vittorio Sebastiano; Samuele Marro; Thomas C Südhof; Marius Wernig
Journal:  Nature       Date:  2011-05-26       Impact factor: 49.962

10.  Direct conversion of fibroblasts to functional neurons by defined factors.

Authors:  Thomas Vierbuchen; Austin Ostermeier; Zhiping P Pang; Yuko Kokubu; Thomas C Südhof; Marius Wernig
Journal:  Nature       Date:  2010-01-27       Impact factor: 49.962
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