Literature DB >> 2420399

Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig.

W J van der Giessen, B Schoutsen, J G Tijssen, P D Verdouw.   

Abstract

Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content.

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Year:  1986        PMID： 2420399      PMCID： PMC1916893          DOI： 10.1111/j.1476-5381.1986.tb10152.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

2.  Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia.

Authors:  A M Lefer; M L Ogletree; J B Smith; M J Silver; K C Nicolaou; W E Barnette; G P Gasic
Journal:  Science       Date:  1978-04-07       Impact factor: 47.728

3.  Rebound recovery of myocardial creatine phosphate with reperfusion after ischemia.

Authors:  K Ichihara; Y Abiko
Journal:  Am Heart J       Date:  1984-12       Impact factor: 4.749

4.  Simultaneous determination of myocardial adenine nucleotides and creatine phosphate by high-performance liquid chromatography.

Authors:  E Harmsen; P P de Tombe; J W de Jong
Journal:  J Chromatogr       Date:  1982-06-11

5.  Beneficial effects of a new carbacyclin derivative, ZK 36 374, in acute myocardial ischemia.

Authors:  K Schrör; R Ohlendorf; H Darius
Journal:  J Pharmacol Exp Ther       Date:  1981-10       Impact factor: 4.030

6.  Improved functional recovery of the isolated rat heart after 24 hours of hypothermic arrest with a stable prostacyclin analogue (ZK 36 374).

Authors:  W H van Gilst; P W Boonstra; J A Terpstra; C R Wildevuur; C D de Langen
Journal:  J Mol Cell Cardiol       Date:  1983-11       Impact factor: 5.000

7.  Prostacyclin--antiarrhythmic or arrhythmogenic? Comparison of the effects of intravenous and intracoronary prostacyclin and ZK36374 during coronary artery occlusion and reperfusion in anaesthetised greyhounds.

Authors:  S J Coker; J R Parratt
Journal:  J Cardiovasc Pharmacol       Date:  1983 Jul-Aug       Impact factor: 3.105

8.  The effects of alinidine, an N-allyl derivative of clonidine, on regional myocardial perfusion and performance in the pig with or without atrial pacing.

Authors:  P D Verdouw; P R Saxena; H C Schamhardt; T M van der Hoek; A M Rutteman
Journal:  Eur J Pharmacol       Date:  1980-06-27       Impact factor: 4.432

9.  Salvage of ischemic myocardium by prostacyclin during experimental myocardial infarction.

Authors:  J A Melin; L C Becker
Journal:  J Am Coll Cardiol       Date:  1983-08       Impact factor: 24.094

10.  The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig.

Authors:  W J van der Giessen; W J Mooi; A M Rutteman; L Berk; P D Verdouw
Journal:  Thromb Res       Date:  1984-10-01       Impact factor: 3.944
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  7 in total

1.  Beneficial effect of beraprost, a prostacyclin-mimetic agent, on post-hypoxic recovery of cardiac function and metabolism in rabbit isolated hearts.

Authors:  K Tanonaka; Y Maruyama; S Takeo
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

2.  Effects of iloprost (ZK 36374) on glutathione status during ischaemia and reperfusion of rabbit isolated hearts.

Authors:  R Ferrari; A Cargnoni; S Curello; G M Boffa; C Ceconi
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

Review 3.  Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning.

Authors:  Roberto Bolli; Ken Shinmura; Xian-Liang Tang; Eitaro Kodani; Yu-Ting Xuan; Yiru Guo; Buddhadeb Dawn
Journal:  Cardiovasc Res       Date:  2002-08-15       Impact factor: 10.787

Review 4.  Iloprost. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures.

Authors:  S M Grant; K L Goa
Journal:  Drugs       Date:  1992-06       Impact factor: 9.546

5.  Effects of dilevalol in the anesthetized pig with a partially occluded coronary artery.

Authors:  M O den Boer; L M Sassen; W J van der Giessen; P R Saxena; P D Verdouw
Journal:  Cardiovasc Drugs Ther       Date:  1990-12       Impact factor: 3.727

6.  Bisoprolol improves perfusion of ischaemic myocardium in anaesthetized pigs.

Authors:  L M Sassen; M O den Boer; R J Rensen; P R Saxena; P D Verdouw
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

7.  Coronary thrombolysis with and without nifedipine in pigs.

Authors:  W J van der Giessen; E Harmsen; P P de Tombe; P G Hugenholtz; P D Verdouw
Journal:  Basic Res Cardiol       Date:  1988 May-Jun       Impact factor: 17.165
  7 in total

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