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Literature DB >> 24195491

Plakinamine M, a steroidal alkaloid from the marine sponge Corticium sp.

Zhenyu Lu¹, Michael Koch, Mary Kay Harper, Teatulohi K Matainaho, Louis R Barrows, Ryan M Van Wagoner, Chris M Ireland.

Abstract

By means of bioassay-guided fractionation, a new steroidal alkaloid, plakinamine M (1), and the known compound, plakinamine L (2), with a unique acyclic side chain, were isolated from the marine sponge Corticium sp. collected from New Britain, Papua New Guinea. The structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The two compounds showed inhibition of Mycobacterium tuberculosis with MIC values of 15.8 and 3.6 μg/mL, respectively.

Entities: CellLine Chemical Disease Species

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Year: 2013 PMID： 24195491 PMCID： PMC3883566 DOI： 10.1021/np400649e

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

5 in total

1. Plakinamine L: a new steroidal alkaloid from the marine sponge Corticium sp.

Authors: Maurice Aknin; Amira Rudi; Yoel Kashman; Jean Vacelet; Emile M Gaydou
Journal: Nat Prod Commun Date: 2010-01 Impact factor: 0.986

2. New steroidal alkaloids from an undescribed sponge of the genus Corticium.

Authors: H S Lee; Y Seo; J R Rho; J Shin; V J Paul
Journal: J Nat Prod Date: 2001-11 Impact factor: 4.050

3. Two steroidal alkaloids from a sponge, Corticium sp.

Authors: J Jurek; P J Scheuer
Journal: J Nat Prod Date: 1994-07 Impact factor: 4.050

4. Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid.

Authors: Michael Koch; Tim S Bugni; Chris D Pond; Mohammad Sondossi; Manah Dindi; Pius Piskaut; Chris M Ireland; Louis R Barrows
Journal: Planta Med Date: 2009-05-14 Impact factor: 3.352

5. Rapid and simple MTT method for rifampicin and isoniazid susceptibility testing of Mycobacterium tuberculosis.

Authors: S Foongladda; D Roengsanthia; W Arjrattanakool; C Chuchottaworn; A Chaiprasert; S G Franzblau
Journal: Int J Tuberc Lung Dis Date: 2002-12 Impact factor: 2.373

5 in total

3 in total

Plakinamine M, a steroidal alkaloid from the marine sponge Corticium sp.

1. Plakinamine L: a new steroidal alkaloid from the marine sponge Corticium sp.

2. New steroidal alkaloids from an undescribed sponge of the genus Corticium.

3. Two steroidal alkaloids from a sponge, Corticium sp.

4. Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid.

5. Rapid and simple MTT method for rifampicin and isoniazid susceptibility testing of Mycobacterium tuberculosis.

Review 1. Chemistry and bioactivities of natural steroidal alkaloids.

2. Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells.

3. Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against Mycobacterium tuberculosis.