The antiinflammatory action of some compounds with antioxidant properties.

Current concepts of the inflammatory process include the formation of oxidation products which have the ability to damage tissue. In a few selected inflammation models which included irritant and immunologic stimulus, some representative compounds with antioxidant activity were studied. A diverse set of responses were obtained, but consistently DPPD and ethoxyquin exhibited antiinflammatory activity. Although it cannot be categorically stated that antioxidant capability leads to antiinflammatory activity, it appears that these data provide a theoretical basis for modulating the inflammatory process.