Literature DB >> 24189516

Crosstalk between mTOR complexes.

Jianling Xie1, Christopher G Proud.   

Abstract

The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.

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Year:  2013        PMID： 24189516     DOI： 10.1038/ncb2877

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Authors:  Yonghao Yu; Sang-Oh Yoon; George Poulogiannis; Qian Yang; Xiaoju Max Ma; Judit Villén; Neil Kubica; Gregory R Hoffman; Lewis C Cantley; Steven P Gygi; John Blenis
Journal:  Science       Date:  2011-06-10       Impact factor: 47.728

Review 2.  mTOR complex 2 signaling and functions.

Authors:  Won Jun Oh; Estela Jacinto
Journal:  Cell Cycle       Date:  2011-07-15       Impact factor: 4.534

3.  Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Authors:  David A Guertin; Deanna M Stevens; Carson C Thoreen; Aurora A Burds; Nada Y Kalaany; Jason Moffat; Michael Brown; Kevin J Fitzgerald; David M Sabatini
Journal:  Dev Cell       Date:  2006-12       Impact factor: 12.270

4.  mTORC2 targets AGC kinases through Sin1-dependent recruitment.

Authors:  Angus J M Cameron; Mark D Linch; Adrian T Saurin; Cristina Escribano; Peter J Parker
Journal:  Biochem J       Date:  2011-10-15       Impact factor: 3.857

5.  SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Authors:  Estela Jacinto; Valeria Facchinetti; Dou Liu; Nelyn Soto; Shiniu Wei; Sung Yun Jung; Qiaojia Huang; Jun Qin; Bing Su
Journal:  Cell       Date:  2006-09-07       Impact factor: 41.582

6.  Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

Authors:  M Pende; S C Kozma; M Jaquet; V Oorschot; R Burcelin; Y Le Marchand-Brustel; J Klumperman; B Thorens; G Thomas
Journal:  Nature       Date:  2000 Dec 21-28       Impact factor: 49.962

Review 7.  mTOR: from growth signal integration to cancer, diabetes and ageing.

Authors:  Roberto Zoncu; Alejo Efeyan; David M Sabatini
Journal:  Nat Rev Mol Cell Biol       Date:  2010-12-15       Impact factor: 94.444

8.  Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Authors:  Attila Garami; Fried J T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas
Journal:  Mol Cell       Date:  2003-06       Impact factor: 17.970

9.  Integrated genomic analyses of ovarian carcinoma.

Authors: 
Journal:  Nature       Date:  2011-06-29       Impact factor: 49.962

10.  Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Authors:  Pengda Liu; Wenjian Gan; Hiroyuki Inuzuka; Adam S Lazorchak; Daming Gao; Omotooke Arojo; Dou Liu; Lixin Wan; Bo Zhai; Yonghao Yu; Min Yuan; Byeong Mo Kim; Shavali Shaik; Suchithra Menon; Steven P Gygi; Tae Ho Lee; John M Asara; Brendan D Manning; John Blenis; Bing Su; Wenyi Wei
Journal:  Nat Cell Biol       Date:  2013-10-27       Impact factor: 28.824
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  21 in total

1.  Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.

Authors:  Nancy J Hançer; Wei Qiu; Christine Cherella; Yedan Li; Kyle D Copps; Morris F White
Journal:  J Biol Chem       Date:  2014-03-20       Impact factor: 5.157

2.  Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics.

Authors:  Stephane Belin; Homaira Nawabi; Chen Wang; Shaojun Tang; Alban Latremoliere; Peter Warren; Hubert Schorle; Ceren Uncu; Clifford J Woolf; Zhigang He; Judith A Steen
Journal:  Neuron       Date:  2015-04-30       Impact factor: 17.173

Review 3.  Roles of mTOR complexes in the kidney: implications for renal disease and transplantation.

Authors:  Daniel Fantus; Natasha M Rogers; Florian Grahammer; Tobias B Huber; Angus W Thomson
Journal:  Nat Rev Nephrol       Date:  2016-08-01       Impact factor: 28.314

4.  Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.

Authors:  Adiel Cohen; Martin Kupiec; Ronit Weisman
Journal:  J Biol Chem       Date:  2014-06-13       Impact factor: 5.157

5.  Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.

Authors:  Graham Dominick; Darlene E Berryman; Edward O List; John J Kopchick; Xinna Li; Richard A Miller; Gonzalo G Garcia
Journal:  Endocrinology       Date:  2014-12-02       Impact factor: 4.736

6.  mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease.

Authors:  Andrés Norambuena; Horst Wallrabe; Lloyd McMahon; Antonia Silva; Eric Swanson; Shahzad S Khan; Daniel Baerthlein; Erin Kodis; Salvatore Oddo; James W Mandell; George S Bloom
Journal:  Alzheimers Dement       Date:  2016-09-29       Impact factor: 21.566

Review 7.  Signaling regulations of neuronal regenerative ability.

Authors:  Yi Lu; Stéphane Belin; Zhigang He
Journal:  Curr Opin Neurobiol       Date:  2014-04-12       Impact factor: 6.627

8.  Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition.

Authors:  Ilaria Passacantilli; Gabriele Capurso; Livia Archibugi; Sara Calabretta; Sara Caldarola; Fabrizio Loreni; Gianfranco Delle Fave; Claudio Sette
Journal:  Oncotarget       Date:  2014-07-30

9.  Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma.

Authors:  Wei-Lin Liu; Ming Gao; Kai-Yuan Tzen; Chiao-Ling Tsai; Feng-Ming Hsu; Ann-Lii Cheng; Jason Chia-Hsien Cheng
Journal:  Oncotarget       Date:  2014-06-15

10.  Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides.

Authors:  Dongmei Wang; Ellen S Mitchell
Journal:  PLoS One       Date:  2016-08-12       Impact factor: 3.240
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