Carlos K H Wong1, Brendan Mulhern2, Yuk-Fai Wan3, Cindy L K Lam3. 1. Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F, Ap Lei Chau Clinic, 161 Ap Lei Chau Main Street, Ap Lei Chau, Hong Kong. Electronic address: carlosho@hku.hk. 2. Health Economics and Decision Science, ScHARR, The University of Sheffield, Sheffield, UK. 3. Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F, Ap Lei Chau Clinic, 161 Ap Lei Chau Main Street, Ap Lei Chau, Hong Kong.
Abstract
OBJECTIVES: To evaluate the responsiveness of generic and mapped preference-based measures based on the anchor of global change in health condition of colorectal cancer (CRC) patients. STUDY DESIGN AND SETTING: A baseline sample of 333 Chinese CRC patients was recruited between September 2009 and July 2010 and was surveyed prospectively at 6-month follow-up. Preference-based indices were derived from the generic SF-6D measure (SF-6DDirect), from the Short Form-12 (SF-6DSF-12), and mapped from the condition-specific Functional Assessment of Cancer Therapy-Colorectal (SF-6DFACT-C). Responsiveness of three measures was assessed using standardized effect size, standardized response mean, responsiveness statistic, and receiver operating characteristic (ROC) curve analysis. RESULTS: The SF-6DSF-12 and SF-6DFACT-C indices were significantly more responsive to detect positive changes than the SF-6DDirect index in improved groups. In worsened group, the SF-6DDirect and SF-6DFACT-C indices showed significant decline from baseline to 6-month follow-up. The areas under the ROC curve for SF-6DDirect and SF-6DFACT-C indices were not statistically different from 0.7. The SF-6DFACT-C index was more responsive to changes in health status compared with other indices. CONCLUSION: Direct SF-6D measure was more responsive than mapped preference-based measures in improved group but the direction was reversed in worsened group. The use of a preference-based index mapped from a condition-specific measure captures both negative and positive important changes among CRC.
OBJECTIVES: To evaluate the responsiveness of generic and mapped preference-based measures based on the anchor of global change in health condition of colorectal cancer (CRC) patients. STUDY DESIGN AND SETTING: A baseline sample of 333 Chinese CRCpatients was recruited between September 2009 and July 2010 and was surveyed prospectively at 6-month follow-up. Preference-based indices were derived from the generic SF-6D measure (SF-6DDirect), from the Short Form-12 (SF-6DSF-12), and mapped from the condition-specific Functional Assessment of Cancer Therapy-Colorectal (SF-6DFACT-C). Responsiveness of three measures was assessed using standardized effect size, standardized response mean, responsiveness statistic, and receiver operating characteristic (ROC) curve analysis. RESULTS: The SF-6DSF-12 and SF-6DFACT-C indices were significantly more responsive to detect positive changes than the SF-6DDirect index in improved groups. In worsened group, the SF-6DDirect and SF-6DFACT-C indices showed significant decline from baseline to 6-month follow-up. The areas under the ROC curve for SF-6DDirect and SF-6DFACT-C indices were not statistically different from 0.7. The SF-6DFACT-C index was more responsive to changes in health status compared with other indices. CONCLUSION: Direct SF-6D measure was more responsive than mapped preference-based measures in improved group but the direction was reversed in worsened group. The use of a preference-based index mapped from a condition-specific measure captures both negative and positive important changes among CRC.
Authors: Edmond P H Choi; Carlos K H Wong; Eric Y F Wan; James H L Tsu; W Y Chin; Kenny Kung; M K Yiu Journal: Qual Life Res Date: 2016-02-23 Impact factor: 4.147
Authors: Carlos K H Wong; Cindy L K Lam; Eric Y F Wan; Anca K C Chan; C H Pak; Frank W K Chan; William C W Wong Journal: Endocrine Date: 2016-09-13 Impact factor: 3.633
Authors: Cindy L K Lam; Esther Y T Yu; Yvonne Y C Lo; Carlos K H Wong; Stewart M Mercer; Daniel Y T Fong; Albert Lee; Tai Pong Lam; Gabriel M Leung Journal: Front Med (Lausanne) Date: 2014-09-15