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Literature DB >> 2418620

Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies.

I Grundke-Iqbal, G P Wang, K Iqbal, Y C Tung, H M Wisniewski.

Abstract

Paired helical filaments (PHF) were isolated from autopsied brain of cases of Alzheimer dementia, and their polypeptides were identified with monoclonal antibodies to PHF by Western blots. The PHF polypeptide profile consisted of several bands with a size difference of less than 5 kilodalton (kDa) between adjacent bands; the most prominent bands were in the 45-62 kDa region. These PHF polypeptides were also labeled with tangles reactive antisera to microtubules from normal brain but had electrophoretic patterns different from those of microtubules and neurofilaments. These studies define the molecular weight profile of PHF polypeptides and suggest that they might originate from normal brain proteins.

Entities: Disease

Mesh：

Substances：

Year: 1985 PMID： 2418620 DOI： 10.1007/bf00690830

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

16 in total

1. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

2. Protein changes in senile dementia.

Authors: K Iqbal; H M Wiśniewski; M L Shelanski; S Brostoff; B H Liwnicz; R D Terry
Journal: Brain Res Date: 1974-09-06 Impact factor: 3.252

3. Microtubule assembly in the absence of added nucleotides.

Authors: M L Shelanski; F Gaskin; C R Cantor
Journal: Proc Natl Acad Sci U S A Date: 1973-03 Impact factor: 11.205

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

5. Observations on the brains of demented old people.

Authors: B E Tomlinson; G Blessed; M Roth
Journal: J Neurol Sci Date: 1970-09 Impact factor: 3.181

6. Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects.

Authors: M Roth; B E Tomlinson; G Blessed
Journal: Nature Date: 1966-01-01 Impact factor: 49.962

7. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea.

Authors: D J Selkoe; Y Ihara; F J Salazar
Journal: Science Date: 1982-03-05 Impact factor: 47.728

8. Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition.

Authors: K Iqbal; T Zaidi; C H Thompson; P A Merz; H M Wisniewski
Journal: Acta Neuropathol Date: 1984 Impact factor: 17.088

9. Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

Authors: I Grundke-Iqbal; A B Johnson; H M Wisniewski; R D Terry; K Iqbal
Journal: Lancet Date: 1979-03-17 Impact factor: 79.321

10. Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules.

Authors: K Iqbal; I Grundke-Iqbal; H M Wisniewski; R D Terry
Journal: Brain Res Date: 1978-02-24 Impact factor: 3.252

11 in total

Review 1. Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.

Authors: K Iqbal; I Grundke-Iqbal
Journal: Mol Neurobiol Date: 1991 Impact factor: 5.590

2. Aluminum neurotoxicity in mammals.

Authors: H M Wisniewski; R C Moretz; J A Sturman; G Y Wen; J W Shek
Journal: Environ Geochem Health Date: 1990-03 Impact factor: 4.609

3. Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.

Authors: C Bancher; H Lassmann; H Budka; I Grundke-Iqbal; K Iqbal; G Wiche; F Seitelberger; H M Wisniewski
Journal: Acta Neuropathol Date: 1987 Impact factor: 17.088

Alzheimer paired helical filaments: identification of polypeptides with monoclonal antibodies.

1. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

2. Protein changes in senile dementia.

3. Microtubule assembly in the absence of added nucleotides.

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

5. Observations on the brains of demented old people.

6. Correlation between scores for dementia and counts of 'senile plaques' in cerebral grey matter of elderly subjects.

7. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea.

8. Alzheimer paired helical filaments: bulk isolation, solubility, and protein composition.

9. Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

10. Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules.

Review 1. Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.

2. Aluminum neurotoxicity in mammals.

3. Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.

4. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

5. The solubility controversy of paired helical filaments: a commentary.

6. Neuroprotective Role of Lazaroids Against Aluminium Chloride Poisoning.

7. Characterization of intracellular amyloid fibrils in the human choroid plexus epithelial cells.

Review 8. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.

9. Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid.

10. Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease.