| Literature DB >> 24184865 |
Shujun Dai1, Zhongqiong Yin, Guiping Yuan, Hongke Lu, Renyong Jia, Jiao Xu, Xu Song, Li Li, Yang Shu, Xiaoxia Liang, Changliang He, Cheng Lv, Wei Zhang.
Abstract
The combined subchronic effects of exposure to lead acetate and cadmium chloride on oxidative stress and metallothionein (MT) gene expression were detected in the liver and kidney of rats to investigate the hazards of environmentally relevant, low-dose exposure to these compounds. Pb and Cd co-induced oxidative stress in liver and kidney tissues. This result was indicated by a significant (P<0.01) increase in the maleic dialdehyde level and decreased levels of reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase. MT mRNA and protein significantly increased (P<0.01) in the liver and kidney of rats. Furthermore, the expression levels of MT-1 mRNA and MT-2 mRNA differed between the liver and kidney. The findings indicate that Pb combined with Cd induced oxidative damage in the liver and kidney of rats, and MT may be a biochemical environmental indicator.Entities:
Keywords: Cd; Metallothionein; Oxidative stress; Pb; Subchronic
Mesh：
Substances：
Year: 2013 PMID： 24184865 DOI： 10.1016/j.etap.2013.10.003
Source DB: PubMed Journal: Environ Toxicol Pharmacol ISSN： 1382-6689 Impact factor: 4.860