Literature DB >> 24184433

DREADDs: novel tools for drug discovery and development.

Hyeong-Min Lee1, Patrick M Giguere1, Bryan L Roth2.   

Abstract

Since the invention of the first designer receptors exclusively activated by designer drugs (DREADDs), these engineered G protein-coupled receptors (GPCRs) have been widely applied in investigations of biological processes and behaviors. DREADD technology has emerged as a powerful tool with great potential for drug discovery and development. DREADDs can facilitate the identification of druggable targets and enable researchers to explore the activities of novel drugs against both known and orphan GPCRs. Here, we discuss how DREADDs can be used as novel tools for drug discovery and development.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24184433      PMCID： PMC4004703          DOI： 10.1016/j.drudis.2013.10.018

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  42 in total

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Review 7.  New concepts in drug discovery: collateral efficacy and permissive antagonism.

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  40 in total

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Review 6.  CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury.

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10.  Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence.

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